[HTML][HTML] Small molecule immunomodulation: the tumor microenvironment and overcoming immune escape
A Osipov, MT Saung, L Zheng, AG Murphy - Journal for immunotherapy of …, 2019 - Springer
Immunotherapy has led to a paradigm shift in the treatment of many advanced malignancies.
Despite the success in treatment of tumors like non-small cell lung cancer (NSCLC) and …
Despite the success in treatment of tumors like non-small cell lung cancer (NSCLC) and …
FDA Approval Summary: Nivolumab Plus Ipilimumab for the Treatment of Patients with Hepatocellular Carcinoma Previously Treated with Sorafenib
MT Saung, L Pelosof, S Casak, M Donoghue… - The …, 2021 - academic.oup.com
Abstract On March 10, 2020, the US Food and Drug Administration (FDA) granted
accelerated approval to nivolumab in combination with ipilimumab for the treatment of …
accelerated approval to nivolumab in combination with ipilimumab for the treatment of …
Current standards of chemotherapy for pancreatic cancer
MT Saung, L Zheng - Clinical therapeutics, 2017 - Elsevier
Purpose Pancreatic cancer has a dismal prognosis due to the early development of systemic
metastatic disease. Chemotherapeutic agents are the only systemic therapy that offers …
metastatic disease. Chemotherapeutic agents are the only systemic therapy that offers …
Probing nanoparticle translocation across the permeable endothelium in experimental atherosclerosis
YT Kim, ME Lobatto, T Kawahara… - Proceedings of the …, 2014 - National Acad Sciences
Therapeutic and diagnostic nanomaterials are being intensely studied for several diseases,
including cancer and atherosclerosis. However, the exact mechanism by which …
including cancer and atherosclerosis. However, the exact mechanism by which …
Effect of computed tomography scanning parameters on gold nanoparticle and iodine contrast
MW Galper, MT Saung, V Fuster, E Roessl… - Investigative …, 2012 - journals.lww.com
Purpose Gold nanoparticles (gold-NPs) have lately been proposed as alternative contrast
agents to iodine-based contrast agents (iodine-CA) for computed tomography (CT) …
agents to iodine-based contrast agents (iodine-CA) for computed tomography (CT) …
Physical and chemical profiles of nanoparticles for lymphatic targeting
Nanoparticles (NPs) have been gaining prominence as delivery vehicles for modulating
immune responses to improve treatments against cancer and autoimmune diseases …
immune responses to improve treatments against cancer and autoimmune diseases …
Dissecting the stromal signaling and regulation of myeloid cells and memory effector T cells in pancreatic cancer
AB Blair, VM Kim, ST Muth, MT Saung, N Lokker… - Clinical Cancer …, 2019 - AACR
Purpose: Myeloid cells are a prominent immunosuppressive component within the stroma of
pancreatic ductal adenocarcinoma (PDAC). Previously, targeting myeloid cells has had …
pancreatic ductal adenocarcinoma (PDAC). Previously, targeting myeloid cells has had …
[HTML][HTML] Targeting myeloid-inflamed tumor with anti-CSF-1R antibody expands CD137+ effector T-cells in the murine model of pancreatic cancer
MT Saung, S Muth, D Ding, DL Thomas… - … for immunotherapy of …, 2018 - Springer
Background The pancreatic cancer vaccine, GVAX, induces novel lymphoid aggregates in
the otherwise immune quiescent pancreatic ductal adenocarcinoma (PDAC). GVAX also …
the otherwise immune quiescent pancreatic ductal adenocarcinoma (PDAC). GVAX also …
CD137 agonist-based combination immunotherapy enhances activated, effector memory T cells and prolongs survival in pancreatic adenocarcinoma
ST Muth, MT Saung, AB Blair, MKG Henderson… - Cancer letters, 2021 - Elsevier
Pancreatic ductal adenocarcinoma (PDAC) is resistant to the PD-1/PD-L1 blockade therapy.
Previously, the combination of PD-1 blockade and vaccine therapy was shown to have a …
Previously, the combination of PD-1 blockade and vaccine therapy was shown to have a …
[HTML][HTML] Interrogating the immune-modulating roles of radiation therapy for a rational combination with immune-checkpoint inhibitors in treating pancreatic cancer
K Fujiwara, MT Saung, H Jing, B Herbst… - … for Immunotherapy of …, 2020 - ncbi.nlm.nih.gov
Background Radiation therapy (RT) has the potential to enhance the efficacy of
immunotherapy, such as checkpoint inhibitors, which has dramatically altered the landscape …
immunotherapy, such as checkpoint inhibitors, which has dramatically altered the landscape …