User profiles for "author:Meggy Suarez-Carmona"

Meggy Suarez-Carmona

German Cancer Research Center
Verified email at dkfz-heidelberg.de
Cited by 2201

EMT and inflammation: inseparable actors of cancer progression

M Suarez‐Carmona, J Lesage, D Cataldo… - Molecular …, 2017 - Wiley Online Library
Tumors can be depicted as wounds that never heal, and are infiltrated by a large array of
inflammatory and immune cells. Tumor‐associated chronic inflammation is a hallmark of …

Defensins:“Simple” antimicrobial peptides or broad-spectrum molecules?

M Suarez-Carmona, P Hubert, P Delvenne… - Cytokine & growth factor …, 2015 - Elsevier
Small cationic peptides highly conserved in vertebrates, both α-and β-defensins were
primarily identified as anti-microbial compounds involved in innate immunity. While human α …

[PDF][PDF] Tumoral immune cell exploitation in colorectal cancer metastases can be targeted effectively by anti-CCR5 therapy in cancer patients

N Halama, I Zoernig, A Berthel, C Kahlert, F Klupp… - Cancer cell, 2016 - cell.com
The immune response influences the clinical course of colorectal cancer (CRC). Analyzing
the invasive margin of human CRC liver metastases, we identified a mechanism of immune …

Radiotherapy orchestrates natural killer cell dependent antitumor immune responses through CXCL8

T Walle, JA Kraske, B Liao, B Lenoir, C Timke… - Science …, 2022 - science.org
Radiotherapy is a mainstay cancer therapy whose antitumor effects partially depend on T
cell responses. However, the role of Natural Killer (NK) cells in radiotherapy remains …

Topography of cancer-associated immune cells in human solid tumors

JN Kather, M Suarez-Carmona, P Charoentong… - Elife, 2018 - elifesciences.org
Lymphoid and myeloid cells are abundant in the tumor microenvironment, can be quantified
by immunohistochemistry and shape the disease course of human solid tumors. Yet, there is …

In Silico Modeling of Immunotherapy and Stroma-Targeting Therapies in Human Colorectal Cancer

JN Kather, J Poleszczuk, M Suarez-Carmona, J Krisam… - Cancer research, 2017 - AACR
Despite the fact that the local immunological microenvironment shapes the prognosis of
colorectal cancer, immunotherapy has shown no benefit for the vast majority of colorectal …

Tissue factor induced by epithelial–mesenchymal transition triggers a procoagulant state that drives metastasis of circulating tumor cells

M Bourcy, M Suarez-Carmona, J Lambert, ME Francart… - Cancer research, 2016 - AACR
Epithelial–mesenchymal transition (EMT) is prominent in circulating tumor cells (CTC), but
how it influences metastatic spread in this setting is obscure. Insofar as blood provides a …

[HTML][HTML] Combined inhibition of CXCL12 and PD-1 in MSS colorectal and pancreatic cancer: modulation of the microenvironment and clinical effects

M Suarez-Carmona, A Williams… - … for Immunotherapy of …, 2021 - ncbi.nlm.nih.gov
Background Immunotherapy in microsatellite stable colorectal or pancreatic cancer has not
shown promising results. It has been hypothesized that targeting immunosuppressive …

Carcinogenic HPV infection in the cervical squamo‐columnar junction

J Mirkovic, BE Howitt, P Roncarati… - The Journal of …, 2015 - Wiley Online Library
Recent studies have suggested the involvement of a unique population of cells at the
cervical squamo‐columnar junction (SCJ) in the pathogenesis of early (squamous …

Soluble factors regulated by epithelial–mesenchymal transition mediate tumour angiogenesis and myeloid cell recruitment

M Suarez‐Carmona, M Bourcy, J Lesage… - The Journal of …, 2015 - Wiley Online Library
Epithelial–mesenchymal transition (EMT) programmes provide cancer cells with invasive
and survival capacities that might favour metastatic dissemination. Whilst signalling …