The epicardium is an epithelial monolayer that plays a central role in heart development and
the myocardial response to injury. Recent developments in our understanding of epicardial …

Enhancing the endogenous regenerative capacity of the mammalian heart is a promising
strategy that can lead to potential treatment of injured cardiac tissues. Studies on heart …

Purpose: Chemoimmunotherapy (chemoIO) is a prevalent first-line treatment for advanced
driver-negative non–small cell lung cancer (NSCLC), with maintenance therapy given after …

Immune checkpoint inhibitors have shown great promise in treating patients with mismatch
repair deficient/microsatellite instability high (dMMR/MSI-H) colorectal cancer (CRC) …

Background Sensitive and reliable biomarkers for early detection of recurrence are needed
to improve post-definitive radiation risk stratification, disease management, and outcomes …

Introduction Immunotherapy (IO) has transformed the treatment paradigm for a wide variety
of solid tumours. However, assessment of response can be challenging with conventional …

Lung branching morphogenesis relies on a number of factors, including proper epithelial
cell proliferation and differentiation, cell polarity, and migration. Rac1, a small Rho GTPase …

Currently, serum carcinoembryonic agent (CEA) along with contrast-enhanced imaging and
colonoscopy are used for evaluation of recurrence of colorectal cancer. However, CEA is an …

Abstract Background Circulating tumor DNA (ctDNA) has emerged as a prognostic and
predictive biomarker for detection of minimal residual disease (MRD), monitoring treatment …

Introduction Immunotherapy (IO) has transformed the treatment paradigm for a wide variety
of solid tumours. However, assessment of response can be challenging with conventional …