Pancreatic ductal adenocarcinoma (PDA) is characterized by its highly immunosuppressive
tumor microenvironment (TME) that limits T cell infiltration and induces T cell hypofunction …

Synthetic receptor signalling has the potential to endow adoptively transferred T cells with
new functions that overcome major barriers in the treatment of solid tumours, including the …

Adoptive cell therapy holds much promise in the treatment of cancer but results in solid
tumors have been modest. The notable exception is tumor-infiltrating lymphocyte (TIL) …

A challenge when targeting T-cell lymphoma with chimeric antigen receptor (CAR) T-cell
therapy is that target antigens are often shared between T cells and tumor cells, resulting in …

Despite the rapid progress in the development of novel adoptive T-cell therapies, the clinical
benefits in treatment of established tumors have remained modest. Several immune evasion …

Cancer treatment with local administration of armed oncolytic viruses could potentially
induce systemic antitumor effects, or the abscopal effect, as they self-amplify in tumors …

Background Ovarian cancers often contain significant numbers of tumor-infiltrating
lymphocytes (TILs) that can be readily harnessed for adoptive T-cell therapy (ACT) …

Despite originating from several different tissues, soft‐tissue sarcomas (STS) are often
grouped together as they share mesenchymal origin and treatment guidelines. Also, with …

Lymphodepleting preconditioning with high-dose chemotherapy is commonly used to
increase the clinical efficacy of adoptive T cell therapy (ACT) strategies, however, with …

Adoptive T-cell transfer is a promising treatment approach for metastatic cancer, but efficacy
in solid tumors has only been achieved with toxic pre-and postconditioning regimens. Thus …