Hepatic, pancreatic, and biliary (HPB) organoids are powerful tools for studying
development, disease, and regeneration. As organoid research expands, the need for clear …

Despite the enormous replication potential of the human liver, there are currently no culture
systems available that sustain hepatocyte replication and/or function in vitro. We have …

Human liver cancer research currently lacks in vitro models that can faithfully recapitulate
the pathophysiology of the original tumor. We recently described a novel, near-physiological …

The gradual accumulation of genetic mutations in human adult stem cells (ASCs) during life
is associated with various age-related diseases, including cancer,. Extreme variation in …

The extracellular matrix (ECM) is essential for cell support during homeostasis and plays a
critical role in cancer. Although research often concentrates on the tumor's cellular aspect …

Background & Aims Cancer-associated fibroblasts (CAFs) play a key role in the cancer
process, but the research progress is hampered by the paucity of preclinical models that are …

Cholangiocarcinoma (CCA) is a rare malignancy that develops at any point along the biliary
tree. CCA has a poor prognosis, its clinical management remains challenging, and effective …

Hepatotropic viruses naturally have narrow host and tissue tropisms, challenging the
development of robust experimental models. The advent of organoid technology provides a …

Prime editing is a recent genome editing technology using fusion proteins of Cas9-nickase
and reverse transcriptase, that holds promise to correct the vast majority of genetic defects …

Cancer stem cells (CSCs) or tumor-initiating cells (TICs) are thought to be the main drivers
for disease progression and treatment resistance across various cancer types. Identifying …