2002). They are non-covalently associated heterodimers consisting of a-and bsubunits. On
the cell surface, integrins exist in a conformation with either high (active) or low (inactive) …

Integrins require an activation step prior to ligand binding and signaling. How talin and
kindlin contribute to these events in non-hematopoietic cells is poorly understood. Here we …

Kindler Syndrome (KS), characterized by transient skin blistering followed by abnormal
pigmentation, skin atrophy, and skin cancer, is caused by mutations in the FERMT1 gene …

Integrin functions are controlled by regulating their affinity for ligand, and by the efficient
recycling of intact integrins through endosomes. Here we demonstrate that the Kindlin …

Kindlin-1 is an integrin tail binding protein that controls integrin activation. Mutations in the
FERMT-1 gene, which encodes for Kindlin-1, lead to Kindler syndrome in man, which is …

Abstract Background Immune checkpoint therapies (ICTs) targeting the programmed cell
death-1 (PD1)/programmed cell death ligand-1 (PD-L1) pathway have improved outcomes …

Background Immuno-oncology and cancer immunotherapies are areas of intense research.
The numbers and locations of CD8+ tumor-infiltrating lymphocytes (TILs) are important …

Tumor programmed cell death ligand-1 (PD-L1) expression is a key biomarker to identify
patients with non-small cell lung cancer who may have an enhanced response to anti …

3079 Background: Tumors use multiple means of immune evasion, notably the programmed
death-1 (PD1)/PDL1 pathway. Anti-PD1/PDL1 therapy induces anti-tumor activity and has …

Background: Malignant mesothelioma is an aggressive cancer with poor prognosis and few
effective therapies. Since mesothelioma is derived from the mesothelium of the lung, we …