Antiangiogenic agents in the management of non-small cell lung cancer: where do we stand now and where are we headed?
C Aggarwal, N Somaiah, G Simon - Cancer biology & therapy, 2012 - Taylor & Francis
Several therapies targeting angiogenesis are currently in development for non-small cell
lung cancer (NSCLC). This review discusses results of recent clinical trials evaluating …
lung cancer (NSCLC). This review discusses results of recent clinical trials evaluating …
[HTML][HTML] Clinical genomic profiling in the management of patients with soft tissue and bone sarcoma
MM Gounder, NP Agaram, SE Trabucco… - Nature …, 2022 - nature.com
There are more than 70 distinct sarcomas, and this diversity complicates the development of
precision-based therapeutics for these cancers. Prospective comprehensive genomic …
precision-based therapeutics for these cancers. Prospective comprehensive genomic …
[HTML][HTML] Novel systemic therapies in advanced liposarcoma: a review of recent clinical trial results
WW Tseng, N Somaiah, AJ Lazar, DC Lev, RE Pollock - Cancers, 2013 - mdpi.com
Liposarcoma is one of the most common adult soft tissue sarcomas an consists of three
histologic subtypes (well and dedifferentiated, myxoid/round cell, and pleomorphic). Surgery …
histologic subtypes (well and dedifferentiated, myxoid/round cell, and pleomorphic). Surgery …
[HTML][HTML] Immuno-genomic landscape of osteosarcoma
CC Wu, HC Beird, J Andrew Livingston… - Nature …, 2020 - nature.com
Limited clinical activity has been seen in osteosarcoma (OS) patients treated with immune
checkpoint inhibitors (ICI). To gain insights into the immunogenic potential of these tumors …
checkpoint inhibitors (ICI). To gain insights into the immunogenic potential of these tumors …
Durvalumab plus tremelimumab in advanced or metastatic soft tissue and bone sarcomas: a single-centre phase 2 trial
Background Few standard treatment options are available for patients with metastatic
sarcomas. We did this trial to evaluate the efficacy, safety, and changes in the tumour …
sarcomas. We did this trial to evaluate the efficacy, safety, and changes in the tumour …
Universal marker and detection tool for human sarcoma circulating tumor cells
To date, no specific marker exists for the detection of circulating tumor cells (CTC) from
different types of sarcomas, though tools are available for detection of CTCs in peripheral …
different types of sarcomas, though tools are available for detection of CTCs in peripheral …
Definition of pRB-and p53-dependent and-independent steps in HIRA/ASF1a-mediated formation of senescence-associated heterochromatin foci
X Ye, B Zerlanko, R Zhang, N Somaiah… - … and cellular biology, 2007 - Am Soc Microbiol
Cellular senescence is an irreversible proliferation arrest triggered by short chromosome
telomeres, activated oncogenes, and cell stress and mediated by the pRB and p53 tumor …
telomeres, activated oncogenes, and cell stress and mediated by the pRB and p53 tumor …
[HTML][HTML] Molecularly targeted therapies in non–small-cell lung cancer annual update 2014
D Morgensztern, MJ Campo, SE Dahlberg… - Journal of Thoracic …, 2015 - Elsevier
There have been significant advances in the understanding of the biology and treatment of
non–small-cell lung cancer (NSCLC) during the past few years. A number of molecularly …
non–small-cell lung cancer (NSCLC) during the past few years. A number of molecularly …
[HTML][HTML] Characteristics and outcomes of patients with advanced sarcoma enrolled in early phase immunotherapy trials
Background Immunotherapies, specifically those based on immune checkpoint inhibitors,
have shown promising activity in multiple tumor types. Other than mifamurtide (MEPACT®) …
have shown promising activity in multiple tumor types. Other than mifamurtide (MEPACT®) …
acccaaaccMDM2-p53 in Liposarcoma: The Need for Targeted Therapies With Novel Mechanisms of Action
N Somaiah, W Tap - Cancer Treatment Reviews, 2023 - Elsevier
Well-differentiated and dedifferentiated liposarcomas (WDLPS and DDLPS) are rare tumors
that arise from lipocytes in soft tissue. There is a high unmet need in patients with these …
that arise from lipocytes in soft tissue. There is a high unmet need in patients with these …