[PDF][PDF] NK cells stimulate recruitment of cDC1 into the tumor microenvironment promoting cancer immune control

JP Böttcher, E Bonavita, P Chakravarty, H Blees… - Cell, 2018 - cell.com
Conventional type 1 dendritic cells (cDC1) are critical for antitumor immunity, and their
abundance within tumors is associated with immune-mediated rejection and the success of …

[PDF][PDF] Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectins

NC Rogers, EC Slack, AD Edwards, MA Nolte… - Immunity, 2005 - cell.com
Pattern-recognition receptors (PRRs) detect molecular signatures of microbes and initiate
immune responses to infection. Prototypical PRRs such as Toll-like receptors (TLRs) signal …

Identification of a dendritic cell receptor that couples sensing of necrosis to immunity

D Sancho, OP Joffre, AM Keller, NC Rogers… - Nature, 2009 - nature.com
Injury or impaired clearance of apoptotic cells leads to the pathological accumulation of
necrotic corpses, which induce an inflammatory response that initiates tissue repair. In …

[HTML][HTML] Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-type lectin

D Sancho, D Mourão-Sá, OP Joffre… - The Journal of …, 2008 - Am Soc Clin Investig
The mouse CD8α+ DC subset excels at cross-presentation of antigen, which can elicit
robust CTL responses. A receptor allowing specific antigen targeting to this subset and its …

Complementation by the protein tyrosine kinase JAK2 of a mutant cell line defective in the interferon-& gamma; signal transduction pathway

D Watling, D Guschin, M Müller, O Silvennoinen… - Nature, 1993 - nature.com
Abstract Interferons (IFNs) & alpha;/& beta;(type I) and & gamma;(type II) bind to distinct cell
surface receptors1, inducing transcription of overlapping sets of genes by intracellular …

[HTML][HTML] Genetic tracing via DNGR-1 expression history defines dendritic cells as a hematopoietic lineage

BU Schraml, J Van Blijswijk, S Zelenay, PG Whitney… - Cell, 2013 - cell.com
Mononuclear phagocytes are classified as macrophages or dendritic cells (DCs) based on
cell morphology, phenotype, or select functional properties. However, these attributes are …

[HTML][HTML] The dendritic cell receptor DNGR-1 controls endocytic handling of necrotic cell antigens to favor cross-priming of CTLs in virus-infected mice

S Zelenay, AM Keller, PG Whitney… - The Journal of …, 2012 - Am Soc Clin Investig
DNGR-1 (CLEC9A) is a receptor for necrotic cells required by DCs to cross-prime CTLs
against dead cell antigens in mice. It is currently unknown how DNGR-1 couples dead cell …

Dendritic cells control fibroblastic reticular network tension and lymph node expansion

SE Acton, AJ Farrugia, JL Astarita, D Mourão-Sá… - Nature, 2014 - nature.com
After immunogenic challenge, infiltrating and dividing lymphocytes markedly increase lymph
node cellularity, leading to organ expansion,. Here we report that the physical elasticity of …

Platelet-derived growth factor induces phosphorylation of multiple JAK family kinases and STAT proteins

ML Vignais, HB Sadowski, D Watling… - … and cellular biology, 1996 - Am Soc Microbiol
Receptors for interferons and other cytokines signal through the action of associated protein
tyrosine kinases of the JAK family and latent cytoplasmic transcription factors of the STAT …

The receptor DNGR-1 signals for phagosomal rupture to promote cross-presentation of dead-cell-associated antigens

J Canton, H Blees, CM Henry, MD Buck, O Schulz… - Nature …, 2021 - nature.com
Abstract Type 1 conventional dendritic (cDC1) cells are necessary for cross-presentation of
many viral and tumor antigens to CD8+ T cells. cDC1 cells can be identified in mice and …