[PDF][PDF] NK cells stimulate recruitment of cDC1 into the tumor microenvironment promoting cancer immune control
Conventional type 1 dendritic cells (cDC1) are critical for antitumor immunity, and their
abundance within tumors is associated with immune-mediated rejection and the success of …
abundance within tumors is associated with immune-mediated rejection and the success of …
[PDF][PDF] Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectins
Pattern-recognition receptors (PRRs) detect molecular signatures of microbes and initiate
immune responses to infection. Prototypical PRRs such as Toll-like receptors (TLRs) signal …
immune responses to infection. Prototypical PRRs such as Toll-like receptors (TLRs) signal …
Identification of a dendritic cell receptor that couples sensing of necrosis to immunity
Injury or impaired clearance of apoptotic cells leads to the pathological accumulation of
necrotic corpses, which induce an inflammatory response that initiates tissue repair. In …
necrotic corpses, which induce an inflammatory response that initiates tissue repair. In …
[HTML][HTML] Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-type lectin
D Sancho, D Mourão-Sá, OP Joffre… - The Journal of …, 2008 - Am Soc Clin Investig
The mouse CD8α+ DC subset excels at cross-presentation of antigen, which can elicit
robust CTL responses. A receptor allowing specific antigen targeting to this subset and its …
robust CTL responses. A receptor allowing specific antigen targeting to this subset and its …
Complementation by the protein tyrosine kinase JAK2 of a mutant cell line defective in the interferon-& gamma; signal transduction pathway
D Watling, D Guschin, M Müller, O Silvennoinen… - Nature, 1993 - nature.com
Abstract Interferons (IFNs) & alpha;/& beta;(type I) and & gamma;(type II) bind to distinct cell
surface receptors1, inducing transcription of overlapping sets of genes by intracellular …
surface receptors1, inducing transcription of overlapping sets of genes by intracellular …
[HTML][HTML] Genetic tracing via DNGR-1 expression history defines dendritic cells as a hematopoietic lineage
Mononuclear phagocytes are classified as macrophages or dendritic cells (DCs) based on
cell morphology, phenotype, or select functional properties. However, these attributes are …
cell morphology, phenotype, or select functional properties. However, these attributes are …
[HTML][HTML] The dendritic cell receptor DNGR-1 controls endocytic handling of necrotic cell antigens to favor cross-priming of CTLs in virus-infected mice
S Zelenay, AM Keller, PG Whitney… - The Journal of …, 2012 - Am Soc Clin Investig
DNGR-1 (CLEC9A) is a receptor for necrotic cells required by DCs to cross-prime CTLs
against dead cell antigens in mice. It is currently unknown how DNGR-1 couples dead cell …
against dead cell antigens in mice. It is currently unknown how DNGR-1 couples dead cell …
Dendritic cells control fibroblastic reticular network tension and lymph node expansion
After immunogenic challenge, infiltrating and dividing lymphocytes markedly increase lymph
node cellularity, leading to organ expansion,. Here we report that the physical elasticity of …
node cellularity, leading to organ expansion,. Here we report that the physical elasticity of …
Platelet-derived growth factor induces phosphorylation of multiple JAK family kinases and STAT proteins
ML Vignais, HB Sadowski, D Watling… - … and cellular biology, 1996 - Am Soc Microbiol
Receptors for interferons and other cytokines signal through the action of associated protein
tyrosine kinases of the JAK family and latent cytoplasmic transcription factors of the STAT …
tyrosine kinases of the JAK family and latent cytoplasmic transcription factors of the STAT …
The receptor DNGR-1 signals for phagosomal rupture to promote cross-presentation of dead-cell-associated antigens
Abstract Type 1 conventional dendritic (cDC1) cells are necessary for cross-presentation of
many viral and tumor antigens to CD8+ T cells. cDC1 cells can be identified in mice and …
many viral and tumor antigens to CD8+ T cells. cDC1 cells can be identified in mice and …