Galectins and their ligands: amplifiers, silencers or tuners of the inflammatory response?

GA Rabinovich, LG Baum, N Tinari, R Paganelli… - Trends in …, 2002 - cell.com
Recent evidence has implicated galectins and their ligands as master regulators of immune
cell homeostasis. Whereas some members of this family, such as galectin-3, behave as …

Intratumoral delivery of immunotherapy—act locally, think globally

MA Aznar, N Tinari, AJ Rullán… - The Journal of …, 2017 - journals.aai.org
Immune mechanisms have evolved to cope with local entry of microbes acting in a confined
fashion but eventually inducing systemic immune memory. Indeed, in situ delivery of a …

90K (Mac-2 BP) and galectins in tumor progression and metastasis

A Grassadonia, N Tinari, I Iurisci, E Piccolo… - Glycoconjugate …, 2002 - Springer
Galectins and their ligands have been implicated in cell transformation and cancer
metastasis, and found to have prognostic value. Mac-2 BP, also known as 90K, is a highly …

A comparative study of the anti-inflammatory, anticoagulant, antiangiogenic, and antiadhesive activities of nine different fucoidans from brown seaweeds

A Cumashi, NA Ushakova, ME Preobrazhenskaya… - …, 2007 - academic.oup.com
The anti-inflammatory, antiangiogenic, anticoagulant, and antiadhesive properties of
fucoidans obtained from nine species of brown algae were studied in order to examine the …

Concentrations of galectin-3 in the sera of normal controls and cancer patients

I Iurisci, N Tinari, C Natoli, D Angelucci, E Cianchetti… - Clinical cancer …, 2000 - AACR
Galectin-3, a member of the β-galactoside-binding animal lectins, has been implicated in
tumor invasion and metastasis. Using an immunoligand assay, we assessed the circulating …

[HTML][HTML] A multicenter study of body mass index in cancer patients treated with anti-PD-1/PD-L1 immune checkpoint inhibitors: when overweight becomes favorable

A Cortellini, M Bersanelli, S Buti, K Cannita… - … for immunotherapy of …, 2019 - Springer
Background Recent evidence suggested a potential correlation between overweight and the
efficacy of immune checkpoint inhibitors (ICIs) in cancer patients. Patients and methods We …

Galectin‐3 overexpression protects from apoptosis by improving cell adhesion properties

P Matarrese, O Fusco, N Tinari, C Natoli… - … journal of cancer, 2000 - Wiley Online Library
Galectin‐3 is a carbohydrate‐binding protein endowed with affinity for β‐galactosides. It
plays a role in cell–cell and cell–matrix interactions. Furthermore, it has been hypothesized …

Galectin‐3 overexpression protects from cell damage and death by influencing mitochondrial homeostasis

P Matarrese, N Tinari, ML Semeraro, C Natoli… - FEBS …, 2000 - Wiley Online Library
Galectins are a family of proteins involved in several cell processes, including their survival
and death. Galectin‐3 has in particular been described as an anti‐apoptotic molecule …

Combination of peripheral neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio is predictive of pathological complete response after neoadjuvant …

V Graziano, A Grassadonia, L Iezzi, P Vici, L Pizzuti… - The Breast, 2019 - Elsevier
The immune system seems to play a fundamental role in breast cancer responsiveness to
chemotherapy. We investigated two peripheral indicators of immunity/inflammation, ie …

Clinical outcomes of patients with advanced cancer and pre‐existing autoimmune diseases treated with anti‐programmed death‐1 immunotherapy: a real‐world …

A Cortellini, S Buti, D Santini, F Perrone, R Giusti… - The …, 2019 - academic.oup.com
Background Patients with a history of autoimmune diseases (AIDs) have not usually been
included in clinical trials with immune checkpoint inhibitors. Materials and Methods …