A re-examination of tetrodotoxin for prolonged duration local anesthesia

DS Kohane, J Yieh, NT Lu, R Langer… - The Journal of the …, 1998 - pubs.asahq.org
Background Highly potent toxins such as tetrodotoxin that block sodium channels with great
specificity have been studied for many years and can provide prolonged blockade when …

A phase I dose escalation study demonstrates quercetin safety and explores potential for bioflavonoid antivirals in patients with chronic hepatitis C

NT Lu, CM Crespi, NM Liu, JQ Vu… - Phytotherapy …, 2016 - Wiley Online Library
The hepatitis C virus (HCV) infects more than 180 million people worldwide, with long‐term
consequences including liver failure and hepatocellular carcinoma. Quercetin bioflavonoids …

The local anesthetic properties and toxicity of saxitonin homologues for rat sciatic nerve block in vivo

DS Kohane, NT Lu, AC Gökgöl-Kline… - Regional Anesthesia & …, 2000 - rapm.bmj.com
Background and Objectives Saxitoxin and its homologues are naturally occurring
compounds that block the sodium channel with high potency. They have the potential for …

[HTML][HTML] Intrathecal trastuzumab: immunotherapy improves the prognosis of leptomeningeal metastases in HER-2+ breast cancer patient

NT Lu, J Raizer, EP Gabor, NM Liu, JQ Vu… - … for immunotherapy of …, 2015 - Springer
We describe the clinical and therapeutic course of a 51-year-old woman with HER-2+ breast
cancer who developed leptomeningeal (LM) and spinal cord metastases after 8 years of …

Vanilloid receptor agonists potentiate the in vivo local anesthetic activity of percutaneously injected site 1 sodium channel blockers

DS Kohane, Y Kuang, NT Lu, R Langer… - The Journal of the …, 1999 - pubs.asahq.org
Background Capsaicin, the pungent ingredient in chili peppers, is a vanilloid with noxious
and analgesic effects that inhibits tetrodotoxin-resistant sodium currents. Because …

Effects of adrenergic agonists and antagonists on tetrodotoxin-induced nerve block

DS Kohane, NT Lu, BE Cairns… - Regional Anesthesia & …, 2001 - rapm.bmj.com
Background and Objectives The relative contributions of α1-, α2-, and β-adrenergic
receptors to adrenergic agonists' prolongation of nerve block by tetrodotoxin (TTX) are …

Oncoprotein stathmin modulates sensitivity to apoptosis in hepatocellular carcinoma cells during hepatitis c viral replication

NT Lu, NM Liu, D Patel, JQ Vu, L Liu… - Journal of Cell …, 2018 - journals.sagepub.com
Patients with chronic hepatitis C virus (HCV) infection risk complications of cirrhosis, liver
failure, and hepatocellular carcinoma (HCC). Previously, our proteomic examination of …

Phospho-network analysis identifies and quantifies hepatitis C virus (HCV)-induced hepatocellular carcinoma (HCC) proteins regulating viral-mediated tumor growth

NT Lu, NM Liu, JQ Vu, D Patel, W Cohn… - Cancer Genomics & …, 2016 - cgp.iiarjournals.org
Background: Patients with chronic hepatitis C virus (HCV) infection are at risk of serious
complications of cirrhosis and hepatocellular carcinoma (HCC). Mass spectrometry (MS) is a …

Molecular analysis and pathology of a second pediatric HIV-associated Burkitt lymphoma

E Cabalo, R Wilkinson, NT Lu, S Shimizu… - Pediatric Pathology & …, 2002 - Taylor & Francis
Diagnosis of a second HIV-associated non-Hodgkin lymphoma (HIV-NHL) is rare, but
additional cases may occur as aggressive therapy for both HIV and NHL improves. An 11 …

[HTML][HTML] Chapter XII. 1. Oncology Treatment Principles

NT Lu - hawaii.edu
A nine year old boy was treated for pharyngitis one month ago. He is now brought in
because his mother notes a decrease in energy, pallor, and easy bruising in his extremities …