Vaccines delivered to the skin by microneedles—with and without adjuvants—have
increased immunogenicity with lower doses than standard vaccine delivery techniques such …

The hallmark function of αβ T cell antigen receptors (TCRs) involves the highly specific co-
recognition of a major histocompatibility complex molecule and its carried peptide. However …

DNA vaccines have many advantages such as thermostability and the ease and rapidity of
manufacture; for example, in an influenza pandemic situation where rapid production of …

Abstract Objectives Vaccines that prime Wilms' tumor 1 (WT1)‐specific CD8+ T cells are
attractive cancer immunotherapies. However, immunogenicity and clinical response rates …

Background Dendritic cells (DCs) are crucial for the efficacy of cancer vaccines, but current
vaccines do not harness the key cDC1 subtype required for effective CD8+ T-cell-mediated …

Mice reconstituted with human hematopoietic stem cells are valuable models to study
aspects of the human immune system in vivo. We describe a humanized mouse model (hu …

The prevalence of autoimmune diseases is on the rise globally. Currently, autoimmunity
presents in over 100 different forms and affects around 9% of the world's population. Current …

Objectives DROSHA and DICER have central roles in the biogenesis of microRNAs
(miRNAs). However, we previously showed that in the murine system, DROSHA has an …

Current HLA-typing methods are typically designed to provide exquisitely-detailed
identification of multiple HLA-alleles to satisfy the requirements for organ and bone marrow …

The distinct properties of allo-reactive T-cell repertoires are not well understood. To
investigate whether auto-reactive and allo-reactive T-cell repertoires encoded distinct …