EGFR heterogeneity and implications for therapeutic intervention in glioblastoma
E Eskilsson, GV Røsland, G Solecki, Q Wang… - Neuro …, 2018 - academic.oup.com
Patients with glioblastoma (GBM) have a universally poor prognosis and are in urgent need
of effective treatment strategies. Recent advances in sequencing techniques unraveled the …
of effective treatment strategies. Recent advances in sequencing techniques unraveled the …
[HTML][HTML] CAR-engineered NK cells for the treatment of glioblastoma: turning innate effectors into precision tools for cancer immunotherapy
Glioblastoma (GB) is the most common and aggressive primary brain tumor in adults and
currently incurable. Despite multimodal treatment regimens, median survival in unselected …
currently incurable. Despite multimodal treatment regimens, median survival in unselected …
DNA methylation-based classification of central nervous system tumours
Accurate pathological diagnosis is crucial for optimal management of patients with cancer.
For the approximately 100 known tumour types of the central nervous system …
For the approximately 100 known tumour types of the central nervous system …
[HTML][HTML] Classification of meningiomas—advances and controversies
Meningiomas are the most frequent primary central nervous system (CNS) tumors. Although
approximately 80% of the tumors are slow growing and benign, some subtypes are …
approximately 80% of the tumors are slow growing and benign, some subtypes are …
Suppression of antitumor T cell immunity by the oncometabolite (R)-2-hydroxyglutarate
Abstract The oncometabolite (R)-2-hydroxyglutarate (R-2-HG) produced by isocitrate
dehydrogenase (IDH) mutations promotes gliomagenesis via DNA and histone methylation …
dehydrogenase (IDH) mutations promotes gliomagenesis via DNA and histone methylation …
ErbB2/HER2-specific NK cells for targeted therapy of glioblastoma
Background: Glioblastoma (GBM) is the most common and malignant intracranial tumor in
adults and currently incurable. To specifically target natural killer (NK) cell activity to GBM …
adults and currently incurable. To specifically target natural killer (NK) cell activity to GBM …
SARS-CoV-2 infects and induces cytotoxic effects in human cardiomyocytes
D Bojkova, JUG Wagner, M Shumliakivska… - Cardiovascular …, 2020 - academic.oup.com
Aims Coronavirus disease 2019 is caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) and has emerged as a global pandemic. SARS-CoV-2 …
coronavirus 2 (SARS-CoV-2) and has emerged as a global pandemic. SARS-CoV-2 …
Integrated molecular-morphologic meningioma classification: a multicenter retrospective analysis, retrospectively and prospectively validated
SLN Maas, D Stichel, T Hielscher, P Sievers… - Journal of clinical …, 2021 - ascopubs.org
PURPOSE Meningiomas are the most frequent primary intracranial tumors. Patient outcome
varies widely from benign to highly aggressive, ultimately fatal courses. Reliable …
varies widely from benign to highly aggressive, ultimately fatal courses. Reliable …
[HTML][HTML] Differential utilization of ketone bodies by neurons and glioma cell lines: a rationale for ketogenic diet as experimental glioma therapy
GD Maurer, DP Brucker, O Bähr, PN Harter… - BMC cancer, 2011 - Springer
Background Even in the presence of oxygen, malignant cells often highly depend on
glycolysis for energy generation, a phenomenon known as the Warburg effect. One strategy …
glycolysis for energy generation, a phenomenon known as the Warburg effect. One strategy …
[HTML][HTML] CDKN2A/B homozygous deletion is associated with early recurrence in meningiomas
P Sievers, T Hielscher, D Schrimpf, D Stichel… - Acta …, 2020 - Springer
Most high-grade meningiomas show a highly perturbed copy number profile and they are
enriched for TERT promoter mutations [6, 7, 11, 12]. In addition, homozygous focal deletions …
enriched for TERT promoter mutations [6, 7, 11, 12]. In addition, homozygous focal deletions …