[HTML][HTML] PD-1 blockade with pembrolizumab in advanced Merkel-cell carcinoma
Background Merkel-cell carcinoma is an aggressive skin cancer that is linked to exposure to
ultraviolet light and the Merkel-cell polyomavirus (MCPyV). Advanced Merkel-cell carcinoma …
ultraviolet light and the Merkel-cell polyomavirus (MCPyV). Advanced Merkel-cell carcinoma …
[HTML][HTML] Avelumab in patients with previously treated metastatic Merkel cell carcinoma: long-term data and biomarker analyses from the single-arm phase 2 JAVELIN …
Background Merkel cell carcinoma (MCC) is a rare, aggressive skin cancer associated with
a high risk of metastasis. In 2017, avelumab (anti–programmed death-ligand 1 (PD-L1)) …
a high risk of metastasis. In 2017, avelumab (anti–programmed death-ligand 1 (PD-L1)) …
Tuberculosis following PD-1 blockade for cancer immunotherapy
Because of the well-established therapeutic benefit of boosting antitumor responses through
blockade of the T cell inhibitory receptor PD-1, it has been proposed that PD-1 blockade …
blockade of the T cell inhibitory receptor PD-1, it has been proposed that PD-1 blockade …
[HTML][HTML] Multidimensional, quantitative assessment of PD-1/PD-L1 expression in patients with Merkel cell carcinoma and association with response to pembrolizumab
NA Giraldo, P Nguyen, EL Engle, GJ Kaunitz… - … for immunotherapy of …, 2018 - Springer
Background We recently reported a 56% objective response rate in patients with advanced
Merkel cell carcinoma (MCC) receiving pembrolizumab. However, a biomarker predicting …
Merkel cell carcinoma (MCC) receiving pembrolizumab. However, a biomarker predicting …
Phase 2 study of pembrolizumab for measurable residual disease in adults with acute lymphoblastic leukemia
RD Cassaday, KLA Garcia, JR Fromm… - Blood …, 2020 - ashpublications.org
The presence of measurable residual disease (MRD) in acute lymphoblastic leukemia (ALL)
confers a poor prognosis. CD19-targeted immunotherapy is effective against MRD but is …
confers a poor prognosis. CD19-targeted immunotherapy is effective against MRD but is …
[PDF][PDF] New interpretable machine-learning method for single-cell data reveals correlates of clinical response to cancer immunotherapy
We introduce a new method for single-cell cytometry studies, FAUST, which performs
unbiased cell population discovery and annotation. FAUST processes experimental data on …
unbiased cell population discovery and annotation. FAUST processes experimental data on …
CD200 expression in neuroendocrine neoplasms
JE Love, K Thompson, MR Kilgore… - American journal of …, 2017 - academic.oup.com
Objectives CD200 expression has been well studied in hematopoietic malignancies;
however, CD200 expression has not been well-characterized in neuroendocrine …
however, CD200 expression has not been well-characterized in neuroendocrine …
T antigen-specific CD8+ T cells associate with PD-1 blockade response in virus-positive Merkel cell carcinoma
UK Hansen, CD Church, AMC Simões… - The Journal of …, 2024 - Am Soc Clin Investig
Merkel cell carcinoma (MCC) is a highly immunogenic skin cancer primarily induced by
Merkel Cell Polyomavirus, driven by the expression of the oncogenic T antigens (T-Ags) …
Merkel Cell Polyomavirus, driven by the expression of the oncogenic T antigens (T-Ags) …
[HTML][HTML] Quality is king: fundamental insights into tumor antigenicity from virus-associated Merkel cell carcinoma
MC Lahman, KG Paulson, PT Nghiem… - Journal of Investigative …, 2021 - Elsevier
Merkel cell carcinoma (MCC) is a rare skin malignancy that is a paradigm cancer for solid
tumor immunotherapy. MCCs associated with Merkel cell polyomavirus (virus-positive MCC …
tumor immunotherapy. MCCs associated with Merkel cell polyomavirus (virus-positive MCC …
Effect of patient immune status on the efficacy of radiation therapy and recurrence-free survival among 805 patients with Merkel cell carcinoma
Purpose Patients with Merkel cell carcinoma (MCC) with chronic immunosuppression (IS)
have worse outcomes, but the mechanisms are not well understood. We hypothesized that …
have worse outcomes, but the mechanisms are not well understood. We hypothesized that …