Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors
Immune checkpoint inhibitors (ICIs) targeting the PD-1/PD-L1 axis induce sustained clinical
responses in a sizable minority of cancer patients. We found that primary resistance to ICIs …
responses in a sizable minority of cancer patients. We found that primary resistance to ICIs …
Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota
Antibodies targeting CTLA-4 have been successfully used as cancer immunotherapy. We
find that the antitumor effects of CTLA-4 blockade depend on distinct Bacteroides species. In …
find that the antitumor effects of CTLA-4 blockade depend on distinct Bacteroides species. In …
New potential and applications of contrast-enhanced ultrasound of the breast: Own investigations and review of the literature
C Balleyguier, P Opolon, MC Mathieu… - European journal of …, 2009 - Elsevier
Imaging of angiogenesis is a challenge for modern imaging. Velocimetry in malignant breast
lesions and density of malignant vessels are very low. In breast imaging, first results of …
lesions and density of malignant vessels are very low. In breast imaging, first results of …
The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide
Cyclophosphamide is one of several clinically important cancer drugs whose therapeutic
efficacy is due in part to their ability to stimulate antitumor immune responses. Studying …
efficacy is due in part to their ability to stimulate antitumor immune responses. Studying …
[PDF][PDF] TET2 inactivation results in pleiotropic hematopoietic abnormalities in mouse and is a recurrent event during human lymphomagenesis
Loss-of-function mutations affecting one or both copies of the Ten-Eleven-translocation
(TET) 2 gene have been described in various human myeloid malignancies. We report that …
(TET) 2 gene have been described in various human myeloid malignancies. We report that …
Gut microbiota signatures are associated with toxicity to combined CTLA-4 and PD-1 blockade
Abstract Treatment with combined immune checkpoint blockade (CICB) targeting CTLA-4
and PD-1 is associated with clinical benefit across tumor types, but also a high rate of …
and PD-1 is associated with clinical benefit across tumor types, but also a high rate of …
Comparison of antisense oligonucleotides and siRNAs in cell culture and in vivo
JR Bertrand, M Pottier, A Vekris, P Opolon… - Biochemical and …, 2002 - Elsevier
Efficiencies of a nuclease resistant antisense oligonucleotide and of siRNA both being
targeted against the green fluorescent protein stably expressed in HeLa cells are compared …
targeted against the green fluorescent protein stably expressed in HeLa cells are compared …
[HTML][HTML] Tumor ablation with irreversible electroporation
B Al-Sakere, F André, C Bernat, E Connault, P Opolon… - PloS one, 2007 - journals.plos.org
We report the first successful use of irreversible electroporation for the minimally invasive
treatment of aggressive cutaneous tumors implanted in mice. Irreversible electroporation is a …
treatment of aggressive cutaneous tumors implanted in mice. Irreversible electroporation is a …
A novel dendritic cell subset involved in tumor immunosurveillance
Abstract The interferon (IFN)-γ–induced TRAIL effector mechanism is a vital component of
cancer immunosurveillance by natural killer (NK) cells in mice,. Here we show that the main …
cancer immunosurveillance by natural killer (NK) cells in mice,. Here we show that the main …
Syncytin-A knockout mice demonstrate the critical role in placentation of a fusogenic, endogenous retrovirus-derived, envelope gene
A Dupressoir, C Vernochet, O Bawa… - Proceedings of the …, 2009 - National Acad Sciences
In most mammalian species, a key process of placenta development is the fusion of
trophoblast cells into a highly specialized, multinucleated syncytiotrophoblast layer, through …
trophoblast cells into a highly specialized, multinucleated syncytiotrophoblast layer, through …