Immune exclusion predicts poor patient outcomes in multiple malignancies, including triple-
negative breast cancer (TNBC). The extracellular matrix (ECM) contributes to immune …

Abstract T cell factor 1 (TCF1) is required for memory and stem-like CD8+ T cell functions.
How TCF1 partners with other transcription factors to regulate transcription remains unclear …

GRB2 is an adaptor protein which interacts with phosphorylated TGF-β receptor and is
critical for mammary tumour growth. We found that TGF-β1-induced EMT increased GRB2 …

Abstract Background Knowledge graphs (KGs) are an important tool for representing
complex relationships between entities in the biomedical domain. Several methods have …

The programmed death-ligand 1 (PD-L1)-dependent immune checkpoint attenuates host
immunity and maintains self-tolerance. Imbalance between protective immunity and …

Myogenesis requires a well-coordinated withdrawal from cell cycle, morphological changes
and cell fusion mediated by actin cytoskeleton. Grb2 is an adaptor protein whose central …

We study the features of the Indian power system and deconstruct the factors that impede its
transition to more optimised market mechanisms. We also present an adaptation of unit …

Finding the right target for a disease is critical in the drug development process. This paper
presents a machine learning approach for predicting gene-disease associations that (i) …

Excessive R-loops, a DNA-RNA hybrid structure, are associated with genome instability and
BRCA1 mutation-related breast cancer. Yet the causality of R-loops in tumorigenesis …

Multiple solid tumor types, including triple-negative breast cancer (TNBC), respond poorly to
immunotherapy due to low infiltration of CD8+ T cells into the tumor core. The extracellular …