User profiles for "author:Pedro Berraondo"

Pedro Berraondo López

Cima Universidad de Navarra
Verified email at unav.es
Cited by 8133

[HTML][HTML] Cytokines in clinical cancer immunotherapy

P Berraondo, MF Sanmamed, MC Ochoa… - British journal of …, 2019 - nature.com
Cytokines are soluble proteins that mediate cell-to-cell communication. Based on the
discovery of the potent anti-tumour activities of several pro-inflammatory cytokines in animal …

IL8, neutrophils, and NETs in a collusion against cancer immunity and immunotherapy

A Teijeira, S Garasa, MC Ochoa, M Villalba… - Clinical Cancer …, 2021 - AACR
One of the most important mechanisms by which cancer fosters its own development is the
generation of an immune microenvironment that inhibits or impairs antitumor immune …

Antibody‐dependent cell cytotoxicity: immunotherapy strategies enhancing effector NK cells

MC Ochoa, L Minute, I Rodriguez… - Immunology and cell …, 2017 - Wiley Online Library
Antibody‐dependent cellular cytotoxicity (ADCC) is a set of mechanisms that target cells
coated with IgG antibodies of the proper subclasses (IgG1 in the human) to be the prey of …

[PDF][PDF] CXCR1 and CXCR2 chemokine receptor agonists produced by tumors induce neutrophil extracellular traps that interfere with immune cytotoxicity

Á Teijeira, S Garasa, M Gato, C Alfaro, I Migueliz… - Immunity, 2020 - cell.com
Neutrophils are expanded and abundant in cancer-bearing hosts. Under the influence of
CXCR1 and CXCR2 chemokine receptor agonists and other chemotactic factors produced …

Neoadjuvant nivolumab modifies the tumor immune microenvironment in resectable glioblastoma

KA Schalper, ME Rodriguez-Ruiz, R Diez-Valle… - Nature medicine, 2019 - nature.com
Glioblastoma is the most common primary central nervous system malignancy and has a
poor prognosis. Standard first-line treatment, which includes surgery followed by adjuvant …

Prophylactic TNF blockade uncouples efficacy and toxicity in dual CTLA-4 and PD-1 immunotherapy

E Perez-Ruiz, L Minute, I Otano, M Alvarez, MC Ochoa… - Nature, 2019 - nature.com
Abstract Combined PD-1 and CTLA-4-targeted immunotherapy with nivolumab and
ipilimumab is effective against melanoma, renal cell carcinoma and non-small-cell lung …

Tumor-produced interleukin-8 attracts human myeloid-derived suppressor cells and elicits extrusion of neutrophil extracellular traps (NETs)

C Alfaro, A Teijeira, C Ońate, G Perez… - Clinical Cancer …, 2016 - AACR
Purpose: Myeloid-derived suppressor cells (MDSC) are considered an important T-cell
immunosuppressive component in cancer-bearing hosts. The factors that attract these cells …

An RNA toolbox for cancer immunotherapy

F Pastor, P Berraondo, I Etxeberria… - Nature Reviews Drug …, 2018 - nature.com
Cancer immunotherapy has revolutionized oncology practice. However, current protein and
cell therapy tools used in cancer immunotherapy are far from perfect, and there is room for …

Targeting NK-cell checkpoints for cancer immunotherapy

A Muntasell, MC Ochoa, L Cordeiro… - Current opinion in …, 2017 - Elsevier
Highlights•NK cells are cytotoxic lymphocytes with potential for cancer immunotherapy.•NK-
cell numbers and function are regulated by surface receptors and cytokines.•Inhibitory and …

Low surface expression of B7-1 (CD80) is an immunoescape mechanism of colon carcinoma

I Tirapu, E Huarte, C Guiducci, A Arina, M Zaratiegui… - Cancer research, 2006 - AACR
Artificially enforced expression of CD80 (B7-1) and CD86 (B7-2) on tumor cells renders
them more immunogenic by triggering the CD28 receptor on T cells. The enigma is that such …