Epigenetic silencing by SETDB1 suppresses tumour intrinsic immunogenicity
Epigenetic dysregulation is a defining feature of tumorigenesis that is implicated in immune
escape,. Here, to identify factors that modulate the immune sensitivity of cancer cells, we …
escape,. Here, to identify factors that modulate the immune sensitivity of cancer cells, we …
Loss of ADAR1 in tumours overcomes resistance to immune checkpoint blockade
Most patients with cancer either do not respond to immune checkpoint blockade or develop
resistance to it, often because of acquired mutations that impair antigen presentation. Here …
resistance to it, often because of acquired mutations that impair antigen presentation. Here …
[HTML][HTML] Systematic discovery of recombinases for efficient integration of large DNA sequences into the human genome
Large serine recombinases (LSRs) are DNA integrases that facilitate the site-specific
integration of mobile genetic elements into bacterial genomes. Only a few LSRs, such as …
integration of mobile genetic elements into bacterial genomes. Only a few LSRs, such as …
In vivo CRISPR screens reveal the landscape of immune evasion pathways across cancer
J Dubrot, PP Du, SK Lane-Reticker, EA Kessler… - Nature …, 2022 - nature.com
The immune system can eliminate tumors, but checkpoints enable immune escape. Here,
we identify immune evasion mechanisms using genome-scale in vivo CRISPR screens …
we identify immune evasion mechanisms using genome-scale in vivo CRISPR screens …
Targeting TBK1 to overcome resistance to cancer immunotherapy
Y Sun, O Revach, S Anderson, EA Kessler, CH Wolfe… - Nature, 2023 - nature.com
Despite the success of PD-1 blockade in melanoma and other cancers, effective treatment
strategies to overcome resistance to cancer immunotherapy are lacking,. Here we identify …
strategies to overcome resistance to cancer immunotherapy are lacking,. Here we identify …
Adaptive stress testing with reward augmentation for autonomous vehicle validatio
Determining possible failure scenarios is a critical step in the evaluation of autonomous
vehicle systems. Real world vehicle testing is commonly employed for autonomous vehicle …
vehicle systems. Real world vehicle testing is commonly employed for autonomous vehicle …
[HTML][HTML] Glioma synapses recruit mechanisms of adaptive plasticity
The role of the nervous system in the regulation of cancer is increasingly appreciated. In
gliomas, neuronal activity drives tumour progression through paracrine signalling factors …
gliomas, neuronal activity drives tumour progression through paracrine signalling factors …
[PDF][PDF] In vivo screens using a selective CRISPR antigen removal lentiviral vector system reveal immune dependencies in renal cell carcinoma
J Dubrot, SK Lane-Reticker, EA Kessler, A Ayer… - Immunity, 2021 - cell.com
CRISPR-Cas9 genome engineering has increased the pace of discovery for immunology
and cancer biology, revealing potential therapeutic targets and providing insight into …
and cancer biology, revealing potential therapeutic targets and providing insight into …
[HTML][HTML] Checkpoint blockade-induced CD8+ T cell differentiation in head and neck cancer responders
Background Immune checkpoint blockade (ICB) response in recurrent/metastatic head and
neck squamous cell carcinoma (HNSCC) is limited to 15%–20% of patients and …
neck squamous cell carcinoma (HNSCC) is limited to 15%–20% of patients and …
[HTML][HTML] Early detection of T-cell lymphoma with T follicular helper phenotype by RHOA mutation analysis
R Dobson, PY Du, L Rásó-Barnett, WQ Yao… - …, 2022 - ncbi.nlm.nih.gov
Angioimmunoblastic T-cell lymphoma (AITL) and peripheral T-cell lymphoma with T follicular
helper phenotype (PTCL-TFH) are a group of complex clinicopathological entities that …
helper phenotype (PTCL-TFH) are a group of complex clinicopathological entities that …