User profiles for "author:Philip S Low"
Philip S. LowProfessor of Chemistry, Purdue University Verified email at purdue.edu Cited by 73128 |
Folate-mediated delivery of macromolecular anticancer therapeutic agents
Y Lu, PS Low - Advanced drug delivery reviews, 2002 - Elsevier
The receptor for folic acid constitutes a useful target for tumor-specific drug delivery,
primarily because:(1) it is upregulated in many human cancers, including malignancies of …
primarily because:(1) it is upregulated in many human cancers, including malignancies of …
Discovery and development of folic-acid-based receptor targeting for imaging and therapy of cancer and inflammatory diseases
PS Low, WA Henne… - Accounts of chemical …, 2008 - ACS Publications
In order to avoid the toxicities associated with prescription drug use today, we have explored
novel methods for delivering drugs selectively to pathologic cells, thereby avoiding the …
novel methods for delivering drugs selectively to pathologic cells, thereby avoiding the …
The FERM domain: a unique module involved in the linkage of cytoplasmic proteins to the membrane
AH Chishti, AC Kim, SM Marfatia, M Lutchman… - Trends in biochemical …, 1998 - cell.com
LETTERS the T7 DNA polymerase ternary complex are directly applicable to KF. A similar
orientation for bound DNA was also obtained when we superposed the pol-ß carboxylate …
orientation for bound DNA was also obtained when we superposed the pol-ß carboxylate …
Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results
GM Van Dam, G Themelis, LMA Crane, NJ Harlaar… - Nature medicine, 2011 - nature.com
The prognosis in advanced-stage ovarian cancer remains poor. Tumor-specific
intraoperative fluorescence imaging may improve staging and debulking efforts in …
intraoperative fluorescence imaging may improve staging and debulking efforts in …
Folate receptor expression in carcinomas and normal tissues determined by a quantitative radioligand binding assay
The folate receptor (FR) is a valuable therapeutic target that is highly expressed on a variety
of cancers. The current development of folate-targeted cancer therapies has created the …
of cancers. The current development of folate-targeted cancer therapies has created the …
In vitro and in vivo two-photon luminescence imaging of single gold nanorods
H Wang, TB Huff, DA Zweifel, W He… - Proceedings of the …, 2005 - National Acad Sciences
Gold nanorods excited at 830 nm on a far-field laser-scanning microscope produced strong
two-photon luminescence (TPL) intensities, with a cos4 dependence on the incident …
two-photon luminescence (TPL) intensities, with a cos4 dependence on the incident …
Rapid stimulation of an oxidative burst during elicitation of cultured plant cells: role in defense and signal transduction
Stimulation of cultured plant cells with elicitors of the defense response leads to the rapid
destruction of a variety of water-soluble compounds including indoleacetic acid and certain …
destruction of a variety of water-soluble compounds including indoleacetic acid and certain …
[HTML][HTML] Delivery of liposomes into cultured KB cells via folate receptor-mediated endocytosis.
Folic acid was covalently conjugated to 66-nm liposomes via spacers of various lengths in
an attempt to target the liposomes to KB cells expressing folate receptors. Spacers of short …
an attempt to target the liposomes to KB cells expressing folate receptors. Spacers of short …
Oxalic Acid, a Pathogenicity Factor for Sclerotinia sclerotiorum, Suppresses the Oxidative Burst of the Host Plant
Effective pathogenesis by the fungus Sclerotinia sclerotiorum requires the secretion of oxalic
acid. Studies were conducted to determine whether oxalate aids pathogen compatibility by …
acid. Studies were conducted to determine whether oxalate aids pathogen compatibility by …
Folate receptor-mediated drug targeting: from therapeutics to diagnostics
AR Hilgenbrink, PS Low - Journal of pharmaceutical sciences, 2005 - Elsevier
Folate targeted drug delivery has emerged as an alternative therapy for the treatment and
imaging of many cancers and inflammatory diseases. Due to its small molecular size and …
imaging of many cancers and inflammatory diseases. Due to its small molecular size and …