User profiles for "author:Philip S Low"

Philip S. Low

Professor of Chemistry, Purdue University
Verified email at purdue.edu
Cited by 73128

Folate-mediated delivery of macromolecular anticancer therapeutic agents

Y Lu, PS Low - Advanced drug delivery reviews, 2002 - Elsevier
The receptor for folic acid constitutes a useful target for tumor-specific drug delivery,
primarily because:(1) it is upregulated in many human cancers, including malignancies of …

Discovery and development of folic-acid-based receptor targeting for imaging and therapy of cancer and inflammatory diseases

PS Low, WA Henne… - Accounts of chemical …, 2008 - ACS Publications
In order to avoid the toxicities associated with prescription drug use today, we have explored
novel methods for delivering drugs selectively to pathologic cells, thereby avoiding the …

The FERM domain: a unique module involved in the linkage of cytoplasmic proteins to the membrane

AH Chishti, AC Kim, SM Marfatia, M Lutchman… - Trends in biochemical …, 1998 - cell.com
LETTERS the T7 DNA polymerase ternary complex are directly applicable to KF. A similar
orientation for bound DNA was also obtained when we superposed the pol-ß carboxylate …

Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results

GM Van Dam, G Themelis, LMA Crane, NJ Harlaar… - Nature medicine, 2011 - nature.com
The prognosis in advanced-stage ovarian cancer remains poor. Tumor-specific
intraoperative fluorescence imaging may improve staging and debulking efforts in …

Folate receptor expression in carcinomas and normal tissues determined by a quantitative radioligand binding assay

N Parker, MJ Turk, E Westrick, JD Lewis, PS Low… - Analytical …, 2005 - Elsevier
The folate receptor (FR) is a valuable therapeutic target that is highly expressed on a variety
of cancers. The current development of folate-targeted cancer therapies has created the …

In vitro and in vivo two-photon luminescence imaging of single gold nanorods

H Wang, TB Huff, DA Zweifel, W He… - Proceedings of the …, 2005 - National Acad Sciences
Gold nanorods excited at 830 nm on a far-field laser-scanning microscope produced strong
two-photon luminescence (TPL) intensities, with a cos4 dependence on the incident …

Rapid stimulation of an oxidative burst during elicitation of cultured plant cells: role in defense and signal transduction

I Apostol, PF Heinstein, PS Low - Plant physiology, 1989 - academic.oup.com
Stimulation of cultured plant cells with elicitors of the defense response leads to the rapid
destruction of a variety of water-soluble compounds including indoleacetic acid and certain …

[HTML][HTML] Delivery of liposomes into cultured KB cells via folate receptor-mediated endocytosis.

RJ Lee, PS Low - Journal of Biological Chemistry, 1994 - Elsevier
Folic acid was covalently conjugated to 66-nm liposomes via spacers of various lengths in
an attempt to target the liposomes to KB cells expressing folate receptors. Spacers of short …

Oxalic Acid, a Pathogenicity Factor for Sclerotinia sclerotiorum, Suppresses the Oxidative Burst of the Host Plant

SG Cessna, VE Sears, MB Dickman, PS Low - The Plant Cell, 2000 - academic.oup.com
Effective pathogenesis by the fungus Sclerotinia sclerotiorum requires the secretion of oxalic
acid. Studies were conducted to determine whether oxalate aids pathogen compatibility by …

Folate receptor-mediated drug targeting: from therapeutics to diagnostics

AR Hilgenbrink, PS Low - Journal of pharmaceutical sciences, 2005 - Elsevier
Folate targeted drug delivery has emerged as an alternative therapy for the treatment and
imaging of many cancers and inflammatory diseases. Due to its small molecular size and …