Vascular endothelial growth factor tyrosine kinase inhibitors (VEGF-TKIs) have been the
mainstay of treatment for patients with advanced renal cell carcinoma (RCC). Despite its …

Epithelial-to-mesenchymal transition (EMT), in which epithelial cells loose their polarity and
become motile mesenchymal cells, is a determinant of melanoma metastasis. We compared …

Background: Recent phase III clinical trials have established the superiority of the anti-PD-1
antibodies pembrolizumab and nivolumab over the anti-CTLA-4 antibody ipilimumab in the …

The global burden of hepatocellular carcinoma (HCC), one of the frequent causes of cancer-
related deaths worldwide, is rapidly increasing partly due to the limited treatment options …

Background To evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of
eftilagimod alpha (efti), a soluble lymphocyte activation gene-3 protein, in combination with …

Breast cancer is one of the major causes of mortality in women worldwide. Accounting for 15–
20% of all breast cancer diagnoses, the triple-negative breast cancer (TNBC) subtype …

Abstract Renal Cell Cancer (RCC) is a heterogeneous tumor that shows both intra-and inter-
heterogeneity. The heterogeneity is displayed not only in different patients but also between …

Hepatocellular carcinoma (HCC) is the most common type of primary hepatic malignancy.
HCC is one of the leading causes of cancer deaths worldwide. The oral multi-tyrosine kinase …

Epithelial-to-mesenchymal transition is a critical process that increases the malignant
potential of melanoma by facilitating invasion and dissemination of tumor cells. This study …

Melanoma is the most common cancer diagnosed in pregnant women and an aggressive
course with poorer outcomes is commonly described during pregnancy or shortly after …