Expression profiling of microRNAs by deep sequencing

CJ Creighton, JG Reid… - Briefings in bioinformatics, 2009 - academic.oup.com
MicroRNAs are short non-coding RNAs that regulate the stability and translation of mRNAs.
Profiling experiments, using microarray or deep sequencing technology, have identified …

Recent developments and therapeutic strategies against hepatocellular carcinoma

M Yarchoan, P Agarwal, A Villanueva, S Rao… - Cancer research, 2019 - AACR
Hepatocellular carcinoma (HCC) has emerged as a major cause of cancer deaths globally.
The landscape of systemic therapy has recently changed, with six additional systemic …

[PDF][PDF] The somatic genomic landscape of chromophobe renal cell carcinoma

CF Davis, CJ Ricketts, M Wang, L Yang, AD Cherniack… - Cancer cell, 2014 - cell.com
We describe the landscape of somatic genomic alterations of 66 chromophobe renal cell
carcinomas (ChRCCs) on the basis of multidimensional and comprehensive …

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

DS Gerhard, L Wagner, EA Feingold… - Genome …, 2004 - europepmc.org
Abstract The National Institutes of Health's Mammalian Gene Collection (MGC) project was
designed to generate and sequence a publicly accessible cDNA resource containing a …

[PDF][PDF] A comprehensive pan-cancer molecular study of gynecologic and breast cancers

AC Berger, A Korkut, RS Kanchi, AM Hegde, W Lenoir… - Cancer cell, 2018 - cell.com
We analyzed molecular data on 2,579 tumors from The Cancer Genome Atlas (TCGA) of
four gynecological types plus breast. Our aims were to identify shared and unique molecular …

Embryonic stem cell microRNAs: defining factors in induced pluripotent (iPS) and cancer (CSC) stem cells?

PH Gunaratne - Current stem cell research & therapy, 2009 - ingentaconnect.com
The discovery of microRNAs (miRNAs-small non-coding RNAs of~ 22 nt) heralded a new
and exciting era in biology. During this period miRNAs have gone from ignominy due to their …

Deletion of Dicer in somatic cells of the female reproductive tract causes sterility

AK Nagaraja, C Andreu-Vieyra, HL Franco… - Molecular …, 2008 - academic.oup.com
Dicer is an evolutionarily conserved ribonuclease III that is necessary for microRNA (miRNA)
processing and the synthesis of small interfering RNAs from long double-stranded RNA …

Molecular profiling uncovers a p53-associated role for microRNA-31 in inhibiting the proliferation of serous ovarian carcinomas and other cancers

CJ Creighton, MD Fountain, Z Yu, AK Nagaraja, H Zhu… - Cancer research, 2010 - AACR
MicroRNAs (miRNA) regulate complex patterns of gene expression, and the relevance of
altered miRNA expression to ovarian cancer remains to be elucidated. By comprehensively …

A link between mir-100 and FRAP1/mTOR in clear cell ovarian cancer

AK Nagaraja, CJ Creighton, Z Yu, H Zhu… - Molecular …, 2010 - academic.oup.com
MicroRNAs (miRNAs) are small noncoding RNAs that direct gene regulation through
translational repression and degradation of complementary mRNA. Although miRNAs have …

Oncogenic lncRNA downregulates cancer cell antigen presentation and intrinsic tumor suppression

Q Hu, Y Ye, LC Chan, Y Li, K Liang, A Lin… - Nature …, 2019 - nature.com
How tumor cells genetically lose antigenicity and evade immune checkpoints remains
largely elusive. We report that tissue-specific expression of the human long noncoding RNA …