NAT10 drives cisplatin chemoresistance by enhancing ac4C-associated DNA repair in bladder cancer

R Xie, L Cheng, M Huang, L Huang, Z Chen, Q Zhang… - Cancer research, 2023 - AACR
Epitranscriptomic RNA modifications constitute a critical gene regulatory component that can
affect cancer progression. Among these, the RNA N4-acetylcytidine (ac4C) modification …

[HTML][HTML] Urine DNA methylation assay enables early detection and recurrence monitoring for bladder cancer

X Chen, J Zhang, W Ruan, M Huang… - The Journal of …, 2020 - Am Soc Clin Investig
BACKGROUND Current methods for the detection and surveillance of bladder cancer (BCa)
are often invasive and/or possess suboptimal sensitivity and specificity, especially in early …

HSF1 facilitates the multistep process of lymphatic metastasis in bladder cancer via a novel PRMT5‐WDR5‐Dependent transcriptional program

M Huang, W Dong, R Xie, J Wu, Q Su… - Cancer …, 2022 - Wiley Online Library
Background Lymphatic metastasis has been associated with poor prognosis in bladder
cancer patients with limited therapeutic options. Emerging evidence shows that heat shock …

[HTML][HTML] Circular RNA ACVR2A suppresses bladder cancer cells proliferation and metastasis through miR-626/EYA4 axis

W Dong, J Bi, H Liu, D Yan, Q He, Q Zhou, Q Wang… - Molecular cancer, 2019 - Springer
Abstract Background Circular RNAs (circRNAs) have been considered to mediate
occurrence and development of human cancers, generally acting as microRNA (miRNA) …

[HTML][HTML] DANCR promotes metastasis and proliferation in bladder cancer cells by enhancing IL-11-STAT3 signaling and CCND1 expression

Z Chen, X Chen, R Xie, M Huang, W Dong, J Han… - Molecular Therapy, 2019 - cell.com
The prognosis for patients with bladder cancer (BCa) with lymph node (LN) metastasis is
poor, and it is not improved by current treatments. Long noncoding RNAs (lncRNAs) are …

Polypyrimidine tract binding protein 1 promotes lymphatic metastasis and proliferation of bladder cancer via alternative splicing of MEIS2 and PKM

R Xie, XU Chen, Z Chen, M Huang, W Dong, P Gu… - Cancer letters, 2019 - Elsevier
Lymph node (LN) metastasis is the leading cause of bladder cancer-related mortality.
Splicing factors facilitate cancer progression by modulating oncogenic variants, but it is …

[HTML][HTML] Long non-coding RNA ATB promotes malignancy of esophageal squamous cell carcinoma by regulating miR-200b/Kindlin-2 axis

Z Li, X Wu, L Gu, Q Shen, W Luo, C Deng, Q Zhou… - Cell death & …, 2017 - nature.com
Esophageal squamous cell carcinoma (ESCC) is one of the leading causes of cancer-
related death, especially in China. In addition, the prognosis of late stage patients is …

[HTML][HTML] UBE2S as a novel ubiquitinated regulator of p16 and β-catenin to promote bone metastasis of prostate cancer

S Peng, X Chen, C Huang, C Yang, M Situ… - … journal of biological …, 2022 - ncbi.nlm.nih.gov
Bone metastasis is the main site of metastasis and causes the most deaths in patients with
prostate cancer (PCa). The mechanism of bone metastasis is complex and not fully clarified …

Cuproptosis illustrates tumor micro-environment features and predicts prostate cancer therapeutic sensitivity and prognosis

B Cheng, C Tang, J Xie, Q Zhou, T Luo, Q Wang… - Life Sciences, 2023 - Elsevier
Background Prostate cancer (PCA) is a common malignant genitourinary tumor that
significantly impacts patient survival. Cuproptosis, a copper-dependent programmed cell …

[HTML][HTML] NONO inhibits lymphatic metastasis of bladder cancer via alternative splicing of SETMAR

R Xie, X Chen, L Cheng, M Huang, Q Zhou, J Zhang… - Molecular Therapy, 2021 - cell.com
Bladder cancer patients with lymph node (LN) metastasis have an extremely poor prognosis
and no effective treatment. The alternative splicing of precursor (pre-) mRNA participates in …