B cell immunotherapy has emerged as a mainstay in the treatment of lymphomas and
autoimmune diseases. Although the microenvironment has recently been demonstrated to …

We have previously demonstrated that B cells can shape the immune response to
Mycobacterium tuberculosis, including the level of neutrophil infiltration and granulomatous …

We have previously shown that early growth response (Egr) 1-deficient mice exhibit female
infertility, reflecting a luteinizing hormone (LH) β deficiency. Egr-1 activates the LHβ gene in …

Members of the DEAD-box family of helicases, distinguished by a core characteristic
sequence of Asp-Glu-Ala-Asp, are expressed in a wide range of prokaryotes and eukaryotes …

Background Cancer immunotherapy has evolved from interferon-alpha (IFNα) and
interleukin-2 in the 1980s to CTLA-4 and PD-1/PD-L1 checkpoint inhibitors (CPIs), the latter …

The nuclear receptor steroidogenic factor-1 (SF-1) is essential for development of the
gonads, adrenal gland, and the ventromedial hypothalamic nucleus. It also regulates the …

The DEAD-box helicase DP103 (Ddx20, Gemin3) is a multifunctional protein that interacts
with Epstein-Barr virus nuclear proteins (EBNA2/EBNA3) and is a part of the spliceosomal …

Removal of pathogenic B lymphocytes by depletion of monoclonal antibodies (mAbs) or
deprivation of B-cell survival factors has demonstrated clinical benefit in both oncologic and …

Clinical response to the anti-CD20 antibody rituximab has been demonstrated to correlate
with the polymorphism in the FcγRIIIa receptor where patients homozygous for the higher …

It has recently been shown that in Xenopus, DNA demethylation at promoter regions may
involve protein-DNA interactions, based on the specificity of the demethylated sites. Utilizing …