Immune profiling and quantitative analysis decipher the clinical role of immune-checkpoint expression in the tumor immune microenvironment of DLBCL
ZY Xu-Monette, M Xiao, Q Au, R Padmanabhan… - Cancer immunology …, 2019 - AACR
Abstract PD-1/L1 and CTLA-4 blockade immunotherapies have been approved for 13 types
of cancers and are being studied in diffuse large B-cell lymphoma (DLBCL), the most …
of cancers and are being studied in diffuse large B-cell lymphoma (DLBCL), the most …
Identification of a small molecule SIRT2 inhibitor with selective tumor cytotoxicity
Y Zhang, Q Au, M Zhang, JR Barber, SC Ng… - … and biophysical research …, 2009 - Elsevier
As a member of the class III histone deacetylases, Sirtuin-2 (SIRT2) is critical in cell cycle
regulation which makes it a potential target for cancer therapeutics. In this study, we …
regulation which makes it a potential target for cancer therapeutics. In this study, we …
Genetic subtyping and phenotypic characterization of the immune microenvironment and MYC/BCL2 double expression reveal heterogeneity in diffuse large B-cell …
ZY Xu-Monette, L Wei, X Fang, Q Au, H Nunns… - Clinical Cancer …, 2022 - AACR
Purpose: Diffuse large B-cell lymphoma (DLBCL) is molecularly and clinically
heterogeneous, and can be subtyped according to genetic alterations, cell-of-origin, or …
heterogeneous, and can be subtyped according to genetic alterations, cell-of-origin, or …
[HTML][HTML] Antitumor immune effects of preoperative sitravatinib and nivolumab in oral cavity cancer: SNOW window-of-opportunity study
Background Sitravatinib, a tyrosine kinase inhibitor that targets TYRO3, AXL, MERTK and
the VEGF receptor family, is predicted to increase the M1 to M2-polarized tumor-associated …
the VEGF receptor family, is predicted to increase the M1 to M2-polarized tumor-associated …
Degradation of newly synthesized polypeptides by ribosome-associated RACK1/c-Jun N-terminal kinase/eukaryotic elongation factor 1A2 complex
V Gandin, GJ Gutierrez, LM Brill… - … and cellular biology, 2013 - Am Soc Microbiol
Folding of newly synthesized polypeptides (NSPs) into functional proteins is a highly
regulated process. Rigorous quality control ensures that NSPs attain their native fold during …
regulated process. Rigorous quality control ensures that NSPs attain their native fold during …
Tumor-infiltrating normal B cells revealed by immunoglobulin repertoire clonotype analysis are highly prognostic and crucial for antitumor immune responses in …
ZY Xu-Monette, Y Li, T Snyder, T Yu, T Lu… - Clinical Cancer …, 2023 - AACR
Purpose: Tumor-infiltrating B lymphocytes (TIL-B) have demonstrated prognostic and
predictive significance in solid cancers. In this study, we aimed to distinguish TIL-Bs from …
predictive significance in solid cancers. In this study, we aimed to distinguish TIL-Bs from …
[HTML][HTML] ERN1 and ALPK1 inhibit differentiation of bi-potential tumor-initiating cells in human breast cancer
J Strietz, SS Stepputtis, BT Preca, C Vannier, MM Kim… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Cancers are heterogeneous by nature. While traditional oncology screens commonly use a
single endpoint of cell viability, altering the phenotype of tumor-initiating cells may reveal …
single endpoint of cell viability, altering the phenotype of tumor-initiating cells may reveal …
Identification of inhibitors of HSF1 functional activity by high-content target-based screening
Q Au, Y Zhang, JR Barber, SC Ng, B Zhang - SLAS Discovery, 2009 - Elsevier
Cancer cells are known to experience a high level of stress and may require constant repair
for survival and proliferation. Recent studies showed that inhibition of heat shock factor 1 …
for survival and proliferation. Recent studies showed that inhibition of heat shock factor 1 …
High-content image-based screening for small-molecule chaperone amplifiers in heat shock
Q Au, P Kanchanastit, JR Barber, SC Ng, B Zhang - SLAS Discovery, 2008 - Elsevier
Heat shock proteins represent the major elements of the cellular stress response that
protects cells from diseases caused by protein misfolding. Small-molecule amplifiers of heat …
protects cells from diseases caused by protein misfolding. Small-molecule amplifiers of heat …
Identification of small-molecule HSF1 amplifiers by high content screening in protection of cells from stress induced injury
B Zhang, Q Au, IS Yoon, MH Tremblay, G Yip… - Biochemical and …, 2009 - Elsevier
Small molecule amplifiers of heat shock response have shown promising results in rescuing
stress related injury through chaperone amplification. Herein, we report the results of a high …
stress related injury through chaperone amplification. Herein, we report the results of a high …