Background Both the validity and the reproducibility of microarray-based clinical research
have been challenged. There is a need for critical review of the statistical analysis and …

Abstract The US National Cancer Institute (NCI), in collaboration with scientists representing
multiple areas of expertise relevant to 'omics'-based test development, has developed a …

Importance Targeted magnetic resonance (MR)/ultrasound fusion prostate biopsy has been
shown to detect prostate cancer. The implications of targeted biopsy alone vs standard …

The development of tumor biomarkers ready for clinical use is complex. We propose a
refined system for biomarker study design, conduct, analysis, and evaluation that …

Human autoimmune diseases are thought to develop through a complex combination of
genetic and environmental factors. Genome-wide linkage searches of autoimmune and …

In spite of the controversy over the role of randomized clinical trials in medical research, the
rationale underlying such trials remains persuasive as compared to recent suggestions for …

Motivation: Microarray techniques provide a valuable way of characterizing the molecular
nature of disease. Unfortunately expense and limited specimen availability often lead to …

DNA microarrays are an important technology for studying gene expression. With a single
hybridization, the level of expression of thousands of genes, or even an entire genome, can …

As diagnostic tests become increasingly important for optimizing the use of drugs to treat
cancers, the co-development of a targeted therapy and its companion diagnostic test is …

The results of treatment of 198 patients with Hodgkin's disease with MOPP
(mechlorethamine, vincristine, procarbazine, and prednisone) were analyzed. Eighty …