User profiles for "author:Romain Banchereau"
Romain BanchereauGenentech Verified email at gene.com Cited by 12591 |
TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells
Therapeutic antibodies that block the programmed death-1 (PD-1)–programmed death-
ligand 1 (PD-L1) pathway can induce robust and durable responses in patients with various …
ligand 1 (PD-L1) pathway can induce robust and durable responses in patients with various …
An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis
MPR Berry, CM Graham, FW McNab, Z Xu, SAA Bloch… - Nature, 2010 - nature.com
Tuberculosis (TB), caused by infection with Mycobacterium tuberculosis, is a major cause of
morbidity and mortality worldwide. Efforts to control it are hampered by difficulties with …
morbidity and mortality worldwide. Efforts to control it are hampered by difficulties with …
Atezolizumab versus chemotherapy in patients with platinum-treated locally advanced or metastatic urothelial carcinoma (IMvigor211): a multicentre, open-label …
Background Few options exist for patients with locally advanced or metastatic urothelial
carcinoma after progression with platinum-based chemotherapy. We aimed to assess the …
carcinoma after progression with platinum-based chemotherapy. We aimed to assess the …
ctDNA guiding adjuvant immunotherapy in urothelial carcinoma
T Powles, ZJ Assaf, N Davarpanah, R Banchereau… - Nature, 2021 - nature.com
Minimally invasive approaches to detect residual disease after surgery are needed to
identify patients with cancer who are at risk for metastatic relapse. Circulating tumour DNA …
identify patients with cancer who are at risk for metastatic relapse. Circulating tumour DNA …
[PDF][PDF] Personalized immunomonitoring uncovers molecular networks that stratify lupus patients
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by loss of
tolerance to nucleic acids and highly diverse clinical manifestations. To assess its molecular …
tolerance to nucleic acids and highly diverse clinical manifestations. To assess its molecular …
Understanding human autoimmunity and autoinflammation through transcriptomics
R Banchereau, AM Cepika… - Annual review of …, 2017 - annualreviews.org
Transcriptomics, the high-throughput characterization of RNAs, has been instrumental in
defining pathogenic signatures in human autoimmunity and autoinflammation. It enabled the …
defining pathogenic signatures in human autoimmunity and autoinflammation. It enabled the …
[PDF][PDF] Intratumoral plasma cells predict outcomes to PD-L1 blockade in non-small cell lung cancer
Inhibitors of the programmed cell death-1 (PD-1/PD-L1) signaling axis are approved to treat
non-small cell lung cancer (NSCLC) patients, based on their significant overall survival (OS) …
non-small cell lung cancer (NSCLC) patients, based on their significant overall survival (OS) …
Peripheral T cell expansion predicts tumour infiltration and clinical response
Despite the resounding clinical success in cancer treatment of antibodies that block the
interaction of PD1 with its ligand PDL1, the mechanisms involved remain unknown. A major …
interaction of PD1 with its ligand PDL1, the mechanisms involved remain unknown. A major …
[HTML][HTML] LRRC15+ myofibroblasts dictate the stromal setpoint to suppress tumour immunity
AT Krishnamurty, JA Shyer, M Thai, V Gandham… - Nature, 2022 - nature.com
Recent single-cell studies of cancer in both mice and humans have identified the
emergence of a myofibroblast population specifically marked by the highly restricted leucine …
emergence of a myofibroblast population specifically marked by the highly restricted leucine …
Clinical efficacy and biomarker analysis of neoadjuvant atezolizumab in operable urothelial carcinoma in the ABACUS trial
Antibodies targeting PD-1 or its ligand 1 PD-L1 such as atezolizumab, have great efficacy in
a proportion of metastatic urothelial cancers,. Biomarkers may facilitate identification of these …
a proportion of metastatic urothelial cancers,. Biomarkers may facilitate identification of these …