Human cytomegalovirus (CMV) infections and relapse of disease remain major problems
after allogeneic stem cell transplantation (allo-SCT), in particular in combination with CMV …

Major limitations of currently investigated αβT cells redirected against cancer by transfer of
tumor-specific αβTCR arise from their low affinity, MHC restriction, and risk to mediate self …

Immunotherapy with innate immune cells has recently evoked broad interest as a novel
treatment option for cancer patients. γ9δ2T cells in particular are emerging as an innate cell …

γ9δ2T cells play a critical role in daily cancer immune surveillance by sensing cancer-
mediated metabolic changes. However, a major limitation of the therapeutic application of …

Background γ9δ2 T cells hold great promise as cancer therapeutics because of their unique
capability of reacting to metabolic changes with tumor cells. However, it has proven very …

Background γ9δ2T cells, which express Vγ9 and Vδ2 chains of the T cell receptor (TCR),
mediate cancer immune surveillance by sensing early metabolic changes in malignant …

Purpose: Engineering T cells with receptors to redirect the immune system against cancer
has most recently been described as a scientific breakthrough. However, a main challenge …

Few cancers can be targeted efficiently by engineered T cell strategies. Here, we show that
γδ T cell antigen receptor (γδ TCR)-mediated cancer metabolome targeting can be …

Abstract γδT cells play an important role in cancer immunosurveillance and are able to
distinguish malignant cells from their healthy counterparts via their γδTCR. This …

Clinical responses with chimeric antigen receptor (CAR) T cells are encouraging, however,
primary resistance and relapse after therapy prevent durable remission in a large fraction of …