Src family kinases (SFKs) are key regulators of cell proliferation, differentiation, and survival.
The expression of these non-receptor tyrosine kinases is strongly correlated with cancer …

A unique aspect of arrestin-3 is its ability to support both receptor-dependent and receptor-
independent signaling. Here, we show that inositol hexakisphosphate (IP6) is a non …

Background Targeted thorium-227 conjugates (TTCs) are an emerging class of targeted
alpha therapies (TATs). Their unique mode of action (MoA) is the induction of difficult-to …

The purpose of this study was to investigate the antitumor activity of regorafenib and
sorafenib in preclinical models of HCC and to assess their mechanism of action by …

Inhibition of intracellular nicotinamide phosphoribosyltransferase (NAMPT) represents a
new mode of action for cancer-targeting antibody–drug conjugates (ADCs) with activity also …

Scaffold proteins tether and orient components of a signaling cascade to facilitate signaling.
Although much is known about how scaffolds colocalize signaling proteins, it is unclear …

The adhesion G protein-coupled receptor (aGPCR) GPR126/ADGRG6 plays an important
role in several physiological functions, such as myelination or peripheral nerve repair. This …

The number of cytotoxic payload classes successfully employed in antibody–drug
conjugates (ADCs) is still rather limited. The identification of ADC payloads with a novel …

A large portion of the human GPCRome is still in the dark and understudied, consisting even
of entire subfamilies of GPCRs such as odorant receptors, class A and C orphans, adhesion …

G protein coupled receptors signal through G proteins or arrestins. A long-standing mystery
in the field is why vertebrates have two non-visual arrestins, arrestin-2 and arrestin-3. These …