Current approaches in dendritic cell generation and future implications for cancer immunotherapy
The discovery of tumor-associated antigens, which are either selectively or preferentially
expressed by tumors, together with an improved insight in dendritic cell biology illustrating …
expressed by tumors, together with an improved insight in dendritic cell biology illustrating …
The immune system in the normal endometrium and implications for endometrial cancer development
A Vanderstraeten, S Tuyaerts, F Amant - Journal of reproductive …, 2015 - Elsevier
Although described for the first time some decades ago, the contribution of the immune
system to the establishment of tumors has not been extensively pursued for a long time …
system to the establishment of tumors has not been extensively pursued for a long time …
Personalized cancer vaccine effectively mobilizes antitumor T cell immunity in ovarian cancer
JL Tanyi, S Bobisse, E Ophir, S Tuyaerts… - Science translational …, 2018 - science.org
We conducted a pilot clinical trial testing a personalized vaccine generated by autologous
dendritic cells (DCs) pulsed with oxidized autologous whole-tumor cell lysate (OCDC) …
dendritic cells (DCs) pulsed with oxidized autologous whole-tumor cell lysate (OCDC) …
Wilms' Tumor Gene 1 (WT1)–loaded dendritic cell immunotherapy in patients with uterine tumors: a phase I/II clinical trial
A Coosemans, A Vanderstraeten, S Tuyaerts… - Anticancer …, 2013 - ar.iiarjournals.org
Aim: Treatment options are limited in uterine cancer, leading to a poor prognosis.
Overexpression of Wilms' tumor gene 1 (WT1), the highest ranked tumor antigen, is attractive …
Overexpression of Wilms' tumor gene 1 (WT1), the highest ranked tumor antigen, is attractive …
CD83 expression on dendritic cells and T cells: correlation with effective immune responses
C Aerts‐Toegaert, C Heirman… - European journal of …, 2007 - Wiley Online Library
Human CD83 is a marker molecule for mature dendritic cells (DC) and is also expressed on
activated B and T cells. Although CD83 has been implicated in immune responses, its …
activated B and T cells. Although CD83 has been implicated in immune responses, its …
Single-step antigen loading and activation of dendritic cells by mRNA electroporation for the purpose of therapeutic vaccination in melanoma patients
A Bonehill, AMT Van Nuffel, J Corthals, S Tuyaerts… - Clinical Cancer …, 2009 - AACR
Purpose: A critical factor determining the effectiveness of currently used dendritic cell (DC)–
based vaccines is the DC activation or maturation status. We have recently shown that the T …
based vaccines is the DC activation or maturation status. We have recently shown that the T …
Trial watch: Dendritic cell (DC)-based immunotherapy for cancer
Dendritic cell (DC)-based vaccination for cancer treatment has seen considerable
development over recent decades. However, this field is currently in a state of flux toward …
development over recent decades. However, this field is currently in a state of flux toward …
Messenger RNA-electroporated dendritic cells presenting MAGE-A3 simultaneously in HLA class I and class II molecules
A Bonehill, C Heirman, S Tuyaerts… - The Journal of …, 2004 - journals.aai.org
An optimal anticancer vaccine probably requires the cooperation of both CD4+ Th cells and
CD8+ CTLs. A promising tool in cancer immunotherapy is, therefore, the genetic …
CD8+ CTLs. A promising tool in cancer immunotherapy is, therefore, the genetic …
[HTML][HTML] Enhancing the T-cell stimulatory capacity of human dendritic cells by co-electroporation with CD40L, CD70 and constitutively active TLR4 encoding mRNA
A Bonehill, S Tuyaerts, AMT Van Nuffel, C Heirman… - Molecular Therapy, 2008 - cell.com
The effectiveness of the dendritic cell (DC) vaccination protocols that are currently in use
could be improved by providing the DCs with a more potent maturation signal. We therefore …
could be improved by providing the DCs with a more potent maturation signal. We therefore …
[HTML][HTML] The controversial role of PD-1 and its ligands in gynecological malignancies
O Marinelli, D Annibali, C Aguzzi, S Tuyaerts… - Frontiers in …, 2019 - frontiersin.org
The programmed death-1 (PD-1, CD279) receptor with its ligands, programmed death
ligand 1 (PD-L1, CD274, B7-H1), and programmed death ligand 2 (PD-L2, CD273, B7-DC) …
ligand 1 (PD-L1, CD274, B7-H1), and programmed death ligand 2 (PD-L2, CD273, B7-DC) …