Consensus guidelines for the detection of immunogenic cell death

O Kepp, L Senovilla, I Vitale, E Vacchelli… - …, 2014 - Taylor & Francis
Apoptotic cells have long been considered as intrinsically tolerogenic or unable to elicit
immune responses specific for dead cell-associated antigens. However, multiple stimuli can …

[HTML][HTML] Consensus guidelines for the definition, detection and interpretation of immunogenic cell death

L Galluzzi, I Vitale, S Warren, S Adjemian… - … for immunotherapy of …, 2020 - ncbi.nlm.nih.gov
Cells succumbing to stress via regulated cell death (RCD) can initiate an adaptive immune
response associated with immunological memory, provided they display sufficient …

[HTML][HTML] Pattern recognition receptors and the host cell death molecular machinery

GP Amarante-Mendes, S Adjemian, LM Branco… - Frontiers in …, 2018 - frontiersin.org
Pattern Recognition Receptors (PRRs) are proteins capable of recognizing molecules
frequently found in pathogens (the so-called Pathogen-Associated Molecular Patterns …

Autophagy-dependent anticancer immune responses induced by chemotherapeutic agents in mice

M Michaud, I Martins, AQ Sukkurwala, S Adjemian… - Science, 2011 - science.org
Antineoplastic chemotherapies are particularly efficient when they elicit immunogenic cell
death, thus provoking an anticancer immune response. Here we demonstrate that …

[PDF][PDF] Anticancer chemotherapy-induced intratumoral recruitment and differentiation of antigen-presenting cells

Y Ma, S Adjemian, SR Mattarollo, T Yamazaki… - Immunity, 2013 - cell.com
The therapeutic efficacy of anthracyclines relies on antitumor immune responses elicited by
dying cancer cells. How chemotherapy-induced cell death leads to efficient antigen …

[HTML][HTML] Cancer cells dying from ferroptosis impede dendritic cell-mediated anti-tumor immunity

B Wiernicki, S Maschalidi, J Pinney, S Adjemian… - Nature …, 2022 - nature.com
Immunogenic cell death significantly contributes to the success of anti-cancer therapies, but
immunogenicity of different cell death modalities widely varies. Ferroptosis, a form of cell …

Chemotherapy-induced antitumor immunity requires formyl peptide receptor 1

E Vacchelli, Y Ma, EE Baracco, A Sistigu, DP Enot… - Science, 2015 - science.org
Antitumor immunity driven by intratumoral dendritic cells contributes to the efficacy of
anthracycline-based chemotherapy in cancer. We identified a loss-of-function allele of the …

An immunosurveillance mechanism controls cancer cell ploidy

L Senovilla, I Vitale, I Martins, M Tailler, C Pailleret… - Science, 2012 - science.org
Cancer cells accommodate multiple genetic and epigenetic alterations that initially activate
intrinsic (cell-autonomous) and extrinsic (immune-mediated) oncosuppressive mechanisms …

Cardiac glycosides exert anticancer effects by inducing immunogenic cell death

L Menger, E Vacchelli, S Adjemian, I Martins… - Science translational …, 2012 - science.org
Some successful chemotherapeutics, notably anthracyclines and oxaliplatin, induce a type
of cell stress and death that is immunogenic, hence converting the patient's dying cancer …

Molecular determinants of immunogenic cell death elicited by anticancer chemotherapy

O Kepp, L Galluzzi, I Martins, F Schlemmer… - Cancer and Metastasis …, 2011 - Springer
The success of some chemo-and radiotherapeutic regimens relies on the induction of
immunogenic tumor cell death and on the induction of an anticancer immune response …