The p38 MAP kinases are a family of serine/threonine protein kinases that play important
roles in cellular responses to external stress signals. Since their identification about 10 years …

A cell undergoes many genetic and epigenetic changes as it transitions to malignancy.
Malignant transformation is also accompanied by a progressive loss of tissue homeostasis …

Severe hemolysis or myolysis occurring during pathological states, such as sickle cell
disease, ischemia reperfusion, and malaria results in high levels of free heme, causing …

Production of interleukin-1 and tumour necrosis factor from stimulated human monocytes is
inhibited by a new series of pyridinyl-imidazole compounds. Using radiolabelled and radio …

The crystal structure has been determined at 2.8 A resolution for a chemically-trapped
covalent reaction intermediate between the Hhal DNA cytosine-lmethyltransferase, S …

Glioblastoma multiforme (GBM) is a malignant astrocytoma of the central nervous system
associated with a median survival time of 15 months, even with aggressive therapy. This …

We present a systematic analysis of sequence motifs found in metazoan protein factors
involved in constitutive pre-mRNA splicing and in alternative splicing regulation. Using …

Ground granulated blast furnace slag (GBFS) has been used to alter the geopolymerisation
behaviour of fly ash. The influence of varying amount of GBFS (5–50%) on the reaction …

Cells change their form and function by assembling actin stress fibers at their base and
exerting traction forces on their extracellular matrix (ECM) adhesions. Individual stress fibers …

Emerging byte-addressable, non-volatile memory technologies offer performance within an
order of magnitude of DRAM, prompting their inclusion in the processor memory subsystem …