Dermatofibrosarcoma protuberans (DFSP) is a cutaneous, locally aggressive spindle cell
tumor of intermediate malignancy. Tumor cells are reactive for CD34 and characterized by at …

Cytokine release syndrome (CRS) is a phenomenon of immune hyperactivation described in
the setting of cellular and bispecific T‐cell engaging immunotherapy. Checkpoint blockade …

Emerging evidence suggests a key contribution to non-alcoholic fatty liver disease (NAFLD)
pathogenesis by Th17 cells. The pathogenic characteristics and mechanisms of hepatic …

Pediatric mesenchymal tumors harboring variant NTRK fusions (ETV6-negative) are being
increasingly described; however, the histologic and clinical features of these variant NTRK …

Masses and masslike lesions of the pancreas are uncommon in the pediatric population.
However, owing to overlapping clinical and imaging features, it can be challenging to …

Mouse mammary tumor virus (MMTV), a member of the betaretroviridae, is the most common
cause of breast cancer (BC) in mice. MMTV is transmitted in mice both in the germline as …

Purpose: In neurofibromatosis type 1 (NF1) and in highly aggressive malignant peripheral
nerve sheath tumors (MPNSTs), constitutively active RAS-GTP and increased MAPK …

Activating non-inherited mutations in the guanine nucleotide-binding protein G (q) subunit
alpha (GNAQ) gene family have been identified in childhood vascular tumors. Patients …

Clinically significant endemic mycoses (fungal infections) in the United States (US) include
Blastomyces dermatitidis, Histoplasma capsulatum, and Coccidioides immitis/posadasii …

Plexiform neurofibromas are benign nerve sheath Schwann cell tumors characterized by
biallelic mutations in the neurofibromatosis type 1 (NF1) tumor suppressor gene. Atypical …