Dendritic cells (DCs) are the main professional antigen-presenting cells for induction of T-
cell adaptive responses. Cancer cells express tumor antigens, including neoantigens …

One of the most important mechanisms by which cancer fosters its own development is the
generation of an immune microenvironment that inhibits or impairs antitumor immune …

Antibody‐dependent cellular cytotoxicity (ADCC) is a set of mechanisms that target cells
coated with IgG antibodies of the proper subclasses (IgG1 in the human) to be the prey of …

Neutrophils are expanded and abundant in cancer-bearing hosts. Under the influence of
CXCR1 and CXCR2 chemokine receptor agonists and other chemotactic factors produced …

Purpose: Myeloid-derived suppressor cells (MDSC) are considered an important T-cell
immunosuppressive component in cancer-bearing hosts. The factors that attract these cells …

Preclinical and clinical evidence indicate that the proimmune effects of radiotherapy can be
synergistically augmented with immunostimulatory mAbs to act both on irradiated tumor …

Neutrophil extracellular traps (NETs) are webs of extracellular nuclear DNA extruded by
dying neutrophils infiltrating tissue. NETs constitute a defence mechanism to entrap and kill …

We present a fast and robust approach to tracking the evolving shape of whole fluorescent
cells in time-lapse series. The proposed tracking scheme involves two steps. First …

Poly I: C is a powerful immune adjuvant as a result of its agonist activities on TLR-3, MDA5
and RIG-I. BO-112 is a nanoplexed formulation of Poly I: C complexed with polyethylenimine …

Retroviral gene transfer of interleukin-12 (IL-12) into T cells markedly enhances antitumor
efficacy upon adoptive transfer but has clinically shown unacceptable severe side effects. To …