The observation that a subset of cancer patients show evidence for spontaneous CD8+ T
cell priming against tumor-associated antigens has generated renewed interest in the innate …

For tumor antigen-specific T cells to effectively control the growth of cancer cells in vivo, they
must gain access to, and function within, the tumor microenvironment. While tumor antigen …

Unexpectedly, many cancers appear to induce a spontaneous adaptive T cell response. The
presence of a T cell infiltrate has been linked to favorable clinical outcome in multiple cancer …

Inhibitory receptors on immune cells are pivotal regulators of immune escape in cancer.
Among these inhibitory receptors, CTLA-4 (targeted clinically by ipilimumab) serves as a …

Spontaneous T cell responses against tumors occur frequently and have prognostic value in
patients. The mechanism of innate immune sensing of immunogenic tumors leading to …

Spontaneous tumor-initiated T cell priming is dependent on IFN-β production by tumor-
resident dendritic cells. On the basis of recent observations indicating that IFN-β expression …

Despite lack of tumor control in many models, spontaneous T cell priming occurs frequently
in response to a growing tumor. However, the innate immune mechanisms that promote …

Regulatory T cells (Treg cells) have a crucial role in the immune system by preventing
autoimmunity, limiting immunopathology, and maintaining immune homeostasis. However …

A major subset of patients with advanced solid tumors show a spontaneous T cell-inflamed
tumor microenvironment, which has prognostic import and is associated with clinical …

Recent evidence has indicated that innate immune sensing of cytosolic DNA in dendritic
cells via the host STING pathway is a major mechanism leading to spontaneous T cell …