User profiles for "author:Seongyeol Park"

Seongyeol Park

Korea Advanced Institute of Science and Technology
Verified email at kaist.ac.kr
Cited by 1579

[PDF][PDF] Clonal history and genetic predictors of transformation into small-cell carcinomas from lung adenocarcinomas

JK Lee, J Lee, S Kim, S Kim, J Youk, S Park… - Journal of clinical …, 2017 - bktimes.net
Purpose Histologic transformation of EGFR mutant lung adenocarcinoma (LADC) into small-
cell lung cancer (SCLC) has been described as one of the major resistant mechanisms for …

Association between expression level of PD1 by tumor-infiltrating CD8+ T cells and features of hepatocellular carcinoma

HD Kim, GW Song, S Park, MK Jung, MH Kim, HJ Kang… - Gastroenterology, 2018 - Elsevier
Background & Aims T-cell exhaustion, or an impaired capacity to secrete cytokines and
proliferate with overexpression of immune checkpoint receptors, occurs during chronic viral …

[PDF][PDF] Tracing oncogene rearrangements in the mutational history of lung adenocarcinoma

JJK Lee, S Park, H Park, S Kim, J Lee, J Lee, J Youk… - Cell, 2019 - cell.com
Mutational processes giving rise to lung adenocarcinomas (LADCs) in non-smokers remain
elusive. We analyzed 138 LADC whole genomes, including 83 cases with minimal …

Clonal dynamics in early human embryogenesis inferred from somatic mutation

S Park, NM Mali, R Kim, JW Choi, J Lee, J Lim, JM Park… - Nature, 2021 - nature.com
Cellular dynamics and fate decision in early human embryogenesis remain largely unknown
owing to the challenges of performing studies in human embryos. Here, we explored whole …

[HTML][HTML] Serotonin signals through a gut-liver axis to regulate hepatic steatosis

W Choi, J Namkung, I Hwang, H Kim, A Lim… - Nature …, 2018 - nature.com
Nonalcoholic fatty liver disease (NAFLD) is increasing in worldwide prevalence, closely
tracking the obesity epidemic, but specific pharmaceutical treatments for NAFLD are lacking …

[PDF][PDF] 4‐1BB Delineates Distinct Activation Status of Exhausted Tumor‐Infiltrating CD8+ T Cells in Hepatocellular Carcinoma

HD Kim, S Park, S Jeong, YJ Lee, H Lee, CG Kim… - …, 2020 - Wiley Online Library
Background and Aims Targeting costimulatory receptors with agonistic antibodies is a
promising cancer immunotherapy option. We aimed to investigate costimulatory receptor …

Mutalisk: a web-based somatic MUTation AnaLyIS toolKit for genomic, transcriptional and epigenomic signatures

J Lee, AJ Lee, JK Lee, J Park, Y Kwon… - Nucleic acids …, 2018 - academic.oup.com
Somatic genome mutations occur due to combinations of various intrinsic/extrinsic
mutational processes and DNA repair mechanisms. Different molecular processes …

[HTML][HTML] 4-1BB co-stimulation further enhances anti-PD-1-mediated reinvigoration of exhausted CD39+ CD8 T cells from primary and metastatic sites of epithelial …

G Leem, J Park, M Jeon, ES Kim, SW Kim… - … for immunotherapy of …, 2020 - ncbi.nlm.nih.gov
Background Responses to immunotherapy vary between different cancer types and sites.
Here, we aimed to investigate features of exhaustion and activation in tumor-infiltrating CD8 …

Advancements of remote data acquisition and processing in unmanned vehicle technologies for water quality monitoring: An extensive review

DY Kwon, J Kim, S Park, S Hong - Chemosphere, 2023 - Elsevier
Regular water quality monitoring is becoming desirable due to the increase in water
pollution caused by both climate change and the generation of industrial chemicals …

MET amplification, protein expression, and mutations in pulmonary adenocarcinoma

S Park, J Koh, DW Kim, M Kim, B Keam, TM Kim… - Lung Cancer, 2015 - Elsevier
Objectives MET amplification, protein expression, and splice mutations at exon 14 are
known to cause dysregulation of the MET/HGF pathway. Our study aimed to confirm the …