[HTML][HTML] Neuroblastoma origin and therapeutic targets for immunotherapy
IV Kholodenko, DV Kalinovsky, II Doronin… - Journal of immunology …, 2018 - hindawi.com
Neuroblastoma is a pediatric solid cancer of heterogeneous clinical behavior. The unique
features of this type of cancer frequently hamper the process of determining clinical …
features of this type of cancer frequently hamper the process of determining clinical …
Multivalency: the hallmark of antibodies used for optimization of tumor targeting by design
SM Deyev, EN Lebedenko - Bioessays, 2008 - Wiley Online Library
High‐precision tumor targeting with conventional therapeutics is based on the concept of the
ideal drug as a “magic bullet”; this became possible after techniques were developed for …
ideal drug as a “magic bullet”; this became possible after techniques were developed for …
Targeted nuclear medicine. Seek and destroy
VM Tolmachev, VI Chernov… - Russian Chemical …, 2022 - iopscience.iop.org
The targeted delivery of radionuclides to tumours holds great promise for diagnosis and
treatment of malignant neoplasms. The development of scaffold proteins has significantly …
treatment of malignant neoplasms. The development of scaffold proteins has significantly …
Design of multivalent complexes using the barnase· barstar module
SM Deyev, R Waibel, EN Lebedenko… - Nature …, 2003 - nature.com
The ribonuclease barnase (12 kDa) and its inhibitor barstar (10 kDa) form a very tight
complex in which all N and C termini are accessible for fusion. Here we exploit this system to …
complex in which all N and C termini are accessible for fusion. Here we exploit this system to …
Biocomputing based on particle disassembly
MP Nikitin, VO Shipunova, SM Deyev… - Nature nanotechnology, 2014 - nature.com
Nanoparticles with biocomputing capabilities could potentially be used to create
sophisticated robotic devices with a variety of biomedical applications, including intelligent …
sophisticated robotic devices with a variety of biomedical applications, including intelligent …
Targeting cancer cells by using an antireceptor antibody-photosensitizer fusion protein
EO Serebrovskaya, EF Edelweiss… - Proceedings of the …, 2009 - National Acad Sciences
Antibody-photosensitizer chemical conjugates are used successfully to kill cancer cells in
photodynamic therapy. However, chemical conjugation of photosensitizers presents several …
photodynamic therapy. However, chemical conjugation of photosensitizers presents several …
Enhancement of the blood-circulation time and performance of nanomedicines via the forced clearance of erythrocytes
The rapid elimination of nanoparticles from the bloodstream by the mononuclear phagocyte
system limits the activity of many nanoparticle formulations. Here, we show that inducing a …
system limits the activity of many nanoparticle formulations. Here, we show that inducing a …
Long-term fate of magnetic particles in mice: A comprehensive study
Safe application of nanoparticles in medicine requires full understanding of their
pharmacokinetics including catabolism in the organism. However, information about …
pharmacokinetics including catabolism in the organism. However, information about …
In vivo blockade of mononuclear phagocyte system with solid nanoparticles: Efficiency and affecting factors
AB Mirkasymov, IV Zelepukin, PI Nikitin… - Journal of controlled …, 2021 - Elsevier
Smart nanomaterials, contrast nanoparticles and drug nanocarriers of advanced targeting
architecture were designed for various biomedical applications. Most of such agents …
architecture were designed for various biomedical applications. Most of such agents …
Laser-synthesized TiN nanoparticles for biomedical applications: Evaluation of safety, biodistribution and pharmacokinetics
Having plasmonic absorption within the biological transparency window, titanium nitride
(TiN) nanoparticles (NPs) can potentially outperform gold counterparts in phototheranostic …
(TiN) nanoparticles (NPs) can potentially outperform gold counterparts in phototheranostic …