[HTML][HTML] Neuroblastoma origin and therapeutic targets for immunotherapy

IV Kholodenko, DV Kalinovsky, II Doronin… - Journal of immunology …, 2018 - hindawi.com
Neuroblastoma is a pediatric solid cancer of heterogeneous clinical behavior. The unique
features of this type of cancer frequently hamper the process of determining clinical …

Multivalency: the hallmark of antibodies used for optimization of tumor targeting by design

SM Deyev, EN Lebedenko - Bioessays, 2008 - Wiley Online Library
High‐precision tumor targeting with conventional therapeutics is based on the concept of the
ideal drug as a “magic bullet”; this became possible after techniques were developed for …

Targeted nuclear medicine. Seek and destroy

VM Tolmachev, VI Chernov… - Russian Chemical …, 2022 - iopscience.iop.org
The targeted delivery of radionuclides to tumours holds great promise for diagnosis and
treatment of malignant neoplasms. The development of scaffold proteins has significantly …

Design of multivalent complexes using the barnase· barstar module

SM Deyev, R Waibel, EN Lebedenko… - Nature …, 2003 - nature.com
The ribonuclease barnase (12 kDa) and its inhibitor barstar (10 kDa) form a very tight
complex in which all N and C termini are accessible for fusion. Here we exploit this system to …

Biocomputing based on particle disassembly

MP Nikitin, VO Shipunova, SM Deyev… - Nature nanotechnology, 2014 - nature.com
Nanoparticles with biocomputing capabilities could potentially be used to create
sophisticated robotic devices with a variety of biomedical applications, including intelligent …

Targeting cancer cells by using an antireceptor antibody-photosensitizer fusion protein

EO Serebrovskaya, EF Edelweiss… - Proceedings of the …, 2009 - National Acad Sciences
Antibody-photosensitizer chemical conjugates are used successfully to kill cancer cells in
photodynamic therapy. However, chemical conjugation of photosensitizers presents several …

Enhancement of the blood-circulation time and performance of nanomedicines via the forced clearance of erythrocytes

MP Nikitin, IV Zelepukin, VO Shipunova… - Nature biomedical …, 2020 - nature.com
The rapid elimination of nanoparticles from the bloodstream by the mononuclear phagocyte
system limits the activity of many nanoparticle formulations. Here, we show that inducing a …

Long-term fate of magnetic particles in mice: A comprehensive study

IV Zelepukin, AV Yaremenko, IN Ivanov, MV Yuryev… - Acs Nano, 2021 - ACS Publications
Safe application of nanoparticles in medicine requires full understanding of their
pharmacokinetics including catabolism in the organism. However, information about …

In vivo blockade of mononuclear phagocyte system with solid nanoparticles: Efficiency and affecting factors

AB Mirkasymov, IV Zelepukin, PI Nikitin… - Journal of controlled …, 2021 - Elsevier
Smart nanomaterials, contrast nanoparticles and drug nanocarriers of advanced targeting
architecture were designed for various biomedical applications. Most of such agents …

Laser-synthesized TiN nanoparticles for biomedical applications: Evaluation of safety, biodistribution and pharmacokinetics

IV Zelepukin, AA Popov, VO Shipunova… - Materials Science and …, 2021 - Elsevier
Having plasmonic absorption within the biological transparency window, titanium nitride
(TiN) nanoparticles (NPs) can potentially outperform gold counterparts in phototheranostic …