Deregulation of the cyclin D‐CDK4/6‐INK4‐RB pathway leading to uncontrolled cell
proliferation, is frequently observed in breast cancer. Currently, three selective CDK4/6 …

Object Patients with moyamoya disease complain of headache before surgery, after surgery,
or in both periods. To clarify the pathophysiological features of these headaches which are …

Moyamoya disease (MMD) is a unique cerebrovascular disease characterized by the
progressive stenosis of large intracranial arteries and a hazy network of basal collaterals …

While molecular subgrouping has revolutionized medulloblastoma classification, the extent
of heterogeneity within subgroups is unknown. Similarity network fusion (SNF) applied to …

Medulloblastoma, the most common malignant paediatric brain tumour, is currently treated
with nonspecific cytotoxic therapies including surgery, whole-brain radiation, and aggressive …

Purpose Reports detailing the prognostic impact of TP53 mutations in medulloblastoma offer
conflicting conclusions. We resolve this issue through the inclusion of molecular subgroup …

Objective Moyamoya disease (MMD) is a cerebrovascular occlusive disease of the bilateral
internal carotid arteries that causes a compensatory abnormal vascular network at the base …

Purpose Medulloblastoma comprises four distinct molecular subgroups: WNT, SHH, Group
3, and Group 4. Current medulloblastoma protocols stratify patients based on clinical …

Background Patients with incomplete surgical resection of medulloblastoma are
controversially regarded as having a marker of high-risk disease, which leads to patients …

The development of targeted anti-cancer therapies through the study of cancer genomes is
intended to increase survival rates and decrease treatment-related toxicity. We treated a …