CD8+ T cell immunological memory of past antigen exposure can confer long-lived
protection against infections or tumors. The fact that CD8+ memory T cells can have features …

Chimeric antigen receptor (CAR) T cell therapy is revolutionizing cancer immunotherapy for
patients with B cell malignancies and is now being developed for solid tumors and chronic …

T cell memory relies on the generation of antigen-specific progenitors with stem-like
properties. However, the identity of these progenitors has remained unclear, precluding a …

The conceptualization of adaptive immunity, founded on the observation of immunological
memory, has served as the basis for modern vaccination and immunotherapy approaches …

Background Obesity is a major risk factor for renal cancer, yet our understanding of its effects
on antitumor immunity and immunotherapy outcomes remains incomplete. Deciphering …

Objective Diet‐induced obesity has been shown to alter immune function in mice, but
distinguishing the effects of obesity from changes in diet composition is complicated. It was …

The pool of beta cell-specific CD8+ T cells in type 1 diabetes (T1D) sustains an autoreactive
potential despite having access to a constant source of antigen. To investigate the long-lived …

Simple Summary Although immune-stimulatory and targeted therapies benefit many patients
with metastatic kidney cancer, a sizeable proportion of patients fail to respond. Recent …

BATF targets T cell exhaustion for termination | Nature Immunology Skip to main content
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Ig secretion by terminally differentiated B cells is an important component of the immune
response to foreign pathogens. Its overproduction is a defining characteristic of several B …