Type I collagen is the most abundant protein in humans, and it helps to maintain the integrity
of many tissues via its interactions with cell surfaces, other extracellular matrix molecules …

Abstract The AACR Project GENIE is an international data-sharing consortium focused on
generating an evidence base for precision cancer medicine by integrating clinical-grade …

Perlecan, a ubiquitous basement membrane heparan sulfate proteoglycan, plays key roles
in blood vessel growth and structural integrity. We discovered that the C terminus of …

Type I collagen, the predominant protein of vertebrates, polymerizes with type III and V
collagens and non-collagenous molecules into large cable-like fibrils, yet how the fibril …

Cerebral cavernous malformations (CCMs) are human vascular malformations caused by
mutations in three genes of unknown function: KRIT1, CCM2 and PDCD10. Here we show …

International cancer registries make real-world genomic and clinical data available, but their
joint analysis remains a challenge. AACR Project GENIE, an international cancer registry …

Angiogenesis depends on proper collagen biosynthesis and cross-linking, and type I
collagen is an ideal angiogenic scaffold, although its mechanism is unknown. We examined …

Big data in healthcare can enable unprecedented understanding of diseases and their
treatment, particularly in oncology. These data may include electronic health records …

Cell surface heparan sulfate proteoglycan (HSPG) interactions with type I collagen may be a
ubiquitous cell adhesion mechanism. However, the HSPG binding sites on type I collagen …

Abstract The American Association for Cancer Research (AACR) Project Genomics
Evidence Neoplasia Information Exchange (GENIE) is an international pan-cancer registry …