BRAFV600E Co-opts a Conserved MHC Class I Internalization Pathway to Diminish Antigen Presentation and CD8+ T-cell Recognition of Melanoma
SD Bradley, Z Chen, B Melendez, A Talukder… - Cancer immunology …, 2015 - AACR
Oncogene activation in tumor cells induces broad and complex cellular changes that
contribute significantly to disease initiation and progression. In melanoma, oncogenic …
contribute significantly to disease initiation and progression. In melanoma, oncogenic …
Cellular architecture of Treponema pallidum: novel flagellum, periplasmic cone, and cell envelope as revealed by cryo electron tomography
High-resolution cryo electron tomography (cryo-ET) was utilized to visualize Treponema
pallidum, the causative agent of syphilis, at the molecular level. Three-dimensional (3D) …
pallidum, the causative agent of syphilis, at the molecular level. Three-dimensional (3D) …
[HTML][HTML] Neoantigen vaccination induces clinical and immunologic responses in non-small cell lung cancer patients harboring EGFR mutations
F Li, L Deng, KR Jackson, AH Talukder… - … for immunotherapy of …, 2021 - ncbi.nlm.nih.gov
Background Neoantigen (NeoAg) peptides displayed at the tumor cell surface by human
leukocyte antigen molecules show exquisite tumor specificity and can elicit T cell mediated …
leukocyte antigen molecules show exquisite tumor specificity and can elicit T cell mediated …
SLC45A2: a melanoma antigen with high tumor selectivity and reduced potential for autoimmune toxicity
J Park, AH Talukder, SA Lim, K Kim, K Pan… - Cancer immunology …, 2017 - AACR
Cytotoxic T lymphocyte (CTL)–based immunotherapies have had remarkable success at
generating objective clinical responses in patients with advanced metastatic melanoma …
generating objective clinical responses in patients with advanced metastatic melanoma …
[HTML][HTML] Vestigial-like 1 is a shared targetable cancer-placenta antigen expressed by pancreatic and basal-like breast cancers
SD Bradley, AH Talukder, I Lai, R Davis… - Nature …, 2020 - nature.com
Cytotoxic T lymphocyte (CTL)-based cancer immunotherapies have shown great promise for
inducing clinical regressions by targeting tumor-associated antigens (TAA). To expand the …
inducing clinical regressions by targeting tumor-associated antigens (TAA). To expand the …
Trouble at the core: BRAF (V600E) drives multiple modes of T-cell suppression in melanoma
SD Bradley, B Melendez, A Talukder, G Lizée - Oncoimmunology, 2016 - Taylor & Francis
Several studies have demonstrated that oncogenic BRAF (V600E) promotes T-cell
suppression in melanoma by upregulating the transcription of a multitude of …
suppression in melanoma by upregulating the transcription of a multitude of …