An explanation for the inherently metastatic and heterogeneous nature of cancers may be
their derivation from distinct stem cells. The type of stem cell from which a neoplasm arises …

The significance of apoptosis in relation to the development and progression of prostate
cancer remains largely undefined, bcl-2 is an oncogene that functions by overriding …

Purpose To determine the dose-limiting toxicity and maximum-tolerated dose of the
proteasome inhibitor bortezomib administered intravenously weekly for 4 every 5 weeks; to …

Background Prostate carcinoma is linked to osteoblasticmetastasis. We therefore
investigated the value of bonetargetedconsolidation therapy in selected patients with …

Purpose: Clinical features characteristic of small-cell prostate carcinoma
(SCPC),“anaplastic,” often emerge during the progression of prostate cancer. We sought to …

Human prostate cancer cell lines are particularly difficult to establish, and most existing cell
lines do not exhibit features commonly seen in human prostate cancer. Most available …

PURPOSE: To determine the activity and toxicity of doxorubicin in combination with cisplatin
and etoposide in patients with small-cell prostate carcinoma (SCPCa) and to characterize …

Background Enzalutamide is a novel antiandrogen with proven efficacy in metastatic
castration-resistant prostate cancer (mCRPC). Objective To evaluate enzalutamide's effects …

Background: Skeletal metastases from renal cell carcinoma are highly destructive vascular
lesions. They pose unique surgical challenges due to the risk of life-threatening hemorrhage …

Ductal adenocarcinoma (DAC) is the most common variant histological subtype of prostate
carcinoma and has an aggressive clinical course. DAC is usually characterized and treated …