[HTML][HTML] Long non-coding RNA MEG3 promotes cisplatin-induced nephrotoxicity through regulating AKT/TSC/mTOR-mediated autophagy

X Jing, J Han, J Zhang, Y Chen, J Yuan… - … journal of biological …, 2021 - ncbi.nlm.nih.gov
Abstract Cis-Diamminedichloroplatinum (II)(DDP)-induced nephrotoxicity (DDPIN) may
cause irreversible renal injury associated with high morbidity and mortality. Current standard …

[HTML][HTML] Local transmission and global dissemination of New Delhi Metallo-Beta-Lactamase (NDM): a whole genome analysis

WX Khong, E Xia, K Marimuthu, W Xu, YY Teo, EL Tan… - BMC genomics, 2016 - Springer
Abstract Background New Delhi metallo-β-lactamase (bla NDM), a plasmid-borne
carbapenemase gene associated with significant mortality and severely limited treatment …

Competing engagement of β-arrestin isoforms balances IGF1R/p53 signaling and controls melanoma cell chemotherapeutic responsiveness

S Cismas, S Pasca, C Crudden… - Molecular cancer …, 2023 - AACR
Constraints on the p53 tumor suppressor pathway have long been associated with the
progression, therapeutic resistance, and poor prognosis of melanoma, the most aggressive …

[HTML][HTML] GABPA-activated TGFBR2 transcription inhibits aggressiveness but is epigenetically erased by oncometabolites in renal cell carcinoma

Z Fang, N Zhang, X Yuan, X Xing, X Li, X Qin… - Journal of Experimental …, 2022 - Springer
Background The ETS transcription factor GABPA has long been thought of as an oncogenic
factor and recently suggested as a target for cancer therapy due to its critical effect on …

[HTML][HTML] A2B adenosine receptor antagonists rescue lymphocyte activity in adenosine-producing patient-derived cancer models

AHM Tay, R Prieto-Díaz, S Neo, L Tong… - … for Immunotherapy of …, 2022 - ncbi.nlm.nih.gov
Background Adenosine is a metabolite that suppresses antitumor immune response of T
and NK cells via extracellular binding to the two subtypes of adenosine-2 receptors, A 2 …

[BOOK][B] Uniquely Nk Cells: The Multifaceted Roles of the Natural Killers

S Neo - 2021 - search.proquest.com
Natural killer cells (NK cells) were primarily discovered through the study of tumor cell
recognition during immune surveillance. Till date, many studies had characterized NK cells …

986 Distinct macrophage metabolism and phenotypic changes in viral and non-alcoholic fatty liver disease (NAFLD) related hepatocellular carcinoma

J Zhao, NEO Shiyong, SV Seow, TWH Shuen… - 2023 - jitc.bmj.com
Background Different aetiologies of hepatocellular carcinoma (HCC) may influence the
tumour microenvironment with implications for immunotherapy. Macrophages, especially the …

939 Unique profile of memory-derived regulatory B cells in viral-driven hepatocellular carcinoma

S Neo, KP Lam - 2023 - jitc.bmj.com
Background The functional plasticity of tumor-infiltrating B (TIL-B) cells spans from an array
of anti-tumor responses to non-canonical immune suppression but yet, its influence on the …

Local transmission and global dissemination of New Delhi metallo-beta-lactamase (NDM): a whole genome analysis.

KWX Khong WeiXin, XEY Xia ErYu, K Marimuthu… - 2016 - cabidigitallibrary.org
Abstract Background: New Delhi metallo-β-lactamase (blaNDM), a plasmid-borne
carbapenemase gene associated with significant mortality and severely limited treatment …