Vimentin, a major constituent of the intermediate filament family of proteins, is ubiquitously
expressed in normal mesenchymal cells and is known to maintain cellular integrity and …

Despite the progress made in the clinical management of sepsis, sepsis morbidity and
mortality rates remain high. The inflammatory pathogenesis and organ injury leading to …

Tumor relapse and metastasis are the primary causes of poor survival rates in patients with
advanced cancer despite successful resection or chemotherapeutic treatment. A primary …

Gene rearrangement during the ontogeny of T-and B-cells generates an enormous
repertoire of T-cell receptor (TCR) and immunoglobulin (Ig) genes. Because of the error …

Background. Despite a multiplicity of clinical trials testing immune checkpoint inhibitors, the
frequency of expression of potential predictive biomarkers is unknown in glioma. Methods. In …

Protein aggregation is a hallmark of multiple human pathologies. Autophagy selectively
degrades protein aggregates via aggrephagy. How selectivity is achieved has been elusive …

Exosomes can mediate a dynamic method of communication between malignancies,
including those sequestered in the central nervous system and the immune system. We …

Premature termination codons (PTCs) can cause the decay of mRNAs in the nuclear fraction
of mammalian cells. This enigmatic nuclear response is of interest because it suggests that …

Glioblastoma is highly enriched with macrophages, and osteopontin (OPN) expression
levels correlate with glioma grade and the degree of macrophage infiltration; thus, we …

RBC membrane-cloaked polymeric nanoparticles represent an emerging nanocarrier
platform with extended circulation in vivo. A lipid-insertion method is employed to …