Purpose Neratinib is an oral, irreversible pan-ErbB receptor tyrosine kinase inhibitor. The
efficacy and safety of neratinib were evaluated in two cohorts of patients with advanced …

Background Icotinib, an oral EGFR tyrosine kinase inhibitor, had shown antitumour activity
and favourable toxicity in early-phase clinical trials. We aimed to investigate whether icotinib …

A dynamic and mutualistic interaction between tumor cells and tumor microenvironment
(TME) promotes the progression and metastasis of solid tumors. Cancer immunotherapy is …

MiR-125a has been characterized as a tumor suppressor in several cancers. However, the
role of miR-125a in cervical cancer is unknown. In this study, we found the expression of …

Intrathoracic lymph node metastases in patients with extrathoracic malignancies are a
common clinical manifestation. Several studies evaluating intrathoracic lymph node …

Long non-coding RNAs (lncRNAs) are a kind of RNAs with regulation that participate
fundamental cellular processes via diverse mechanisms. Despite the potential importance of …

Background The V325 study showed that docetaxel, cisplatin, and fluorouracil (DCF)
prolonged overall survival (OS) of patients with advanced gastric cancer, but with a high …

The main aim of this study is to investigate whether baseline lactate dehydrogenase (LDH)
is associated with the clinical outcome of non small‐cell lung cancer (NSCLC) patients …

To examine the relationship between cytotoxic T lymphocyte antigen 4 (CTLA-4) expression
and breast cancer prognosis, CTLA-4 expression was immunohistochemically detected in …

Anti-angiogenesis is an important and promising strategy in cancer therapy. However, the
current methods using anti-vascular endothelial growth factor A (VEGFA) antibodies or …