[HTML][HTML] A reproducible bioprinted 3D tumor model serves as a preselection tool for CAR T cell therapy optimization
L Grunewald, T Lam, L Andersch, A Klaus… - Frontiers in …, 2021 - frontiersin.org
Chimeric antigen receptor (CAR) T cell performance against solid tumors in mouse models
and clinical trials is often less effective than predicted by CAR construct selection in two …
and clinical trials is often less effective than predicted by CAR construct selection in two …
Proplatelet formation is selectively inhibited by collagen type I through Syk-independent GPVI signaling
D Semeniak, R Kulawig, D Stegner… - Journal of cell …, 2016 - journals.biologists.com
Collagen receptors GPVI (also known as GP6) and integrin α2β1 are highly expressed on
blood platelets and megakaryocytes, their immediate precursors. After vessel injury …
blood platelets and megakaryocytes, their immediate precursors. After vessel injury …
[HTML][HTML] CD171-and GD2-specific CAR-T cells potently target retinoblastoma cells in preclinical in vitro testing
L Andersch, J Radke, A Klaus, S Schwiebert, A Winkler… - BMC cancer, 2019 - Springer
Background Chimeric antigen receptor (CAR)-based T cell therapy is in early clinical trials to
target the neuroectodermal tumor, neuroblastoma. No preclinical or clinical efficacy data are …
target the neuroectodermal tumor, neuroblastoma. No preclinical or clinical efficacy data are …
[HTML][HTML] Tumor-Derived Extracellular Vesicles Impair CD171-Specific CD4+ CAR T Cell Efficacy
S Ali, K Toews, S Schwiebert, A Klaus… - Frontiers in …, 2020 - frontiersin.org
Chimeric antigen receptor (CAR) T cell efficacy against solid tumors is currently limited by
several immune escape mechanisms, which may include tumor-derived extracellular …
several immune escape mechanisms, which may include tumor-derived extracellular …
[HTML][HTML] CD28 co-stimulus achieves superior CAR T cell effector function against solid tumors than 4-1BB co-stimulus
A Textor, L Grunewald, K Anders, A Klaus… - Cancers, 2021 - mdpi.com
Simple Summary Efficient trafficking and survival of CAR T cells within the hostile tumor
microenvironment are important prerequisites for potent solid tumor attack that have not yet …
microenvironment are important prerequisites for potent solid tumor attack that have not yet …
[HTML][HTML] Combination of GD2-directed bispecific trifunctional antibody therapy with Pd-1 immune checkpoint blockade induces anti-neuroblastoma immunity in a …
SM Ivasko, K Anders, L Grunewald… - Frontiers in …, 2023 - frontiersin.org
Introduction Despite advances in treating high-risk neuroblastoma, 50-60% of patients still
suffer relapse, necessitating new treatment options. Bispecific trifunctional antibodies (trAbs) …
suffer relapse, necessitating new treatment options. Bispecific trifunctional antibodies (trAbs) …
[HTML][HTML] Two patterns of thrombopoietin signaling suggest no coupling between platelet production and thrombopoietin reactivity in thrombocytopenia-absent radii …
J Fiedler, G Strauß, M Wannack, S Schwiebert… - …, 2012 - ncbi.nlm.nih.gov
Background Thrombocytopenia with absent radii syndrome is defined by bilateral radius
aplasia and thrombocytopenia. Due to impaired thrombopoietin signaling there are only few …
aplasia and thrombocytopenia. Due to impaired thrombopoietin signaling there are only few …
[HTML][HTML] GD2-directed bispecific trifunctional antibody outperforms dinutuximab beta in a murine model for aggressive metastasized neuroblastoma
F Zirngibl, SM Ivasko, L Grunewald… - … for Immunotherapy of …, 2021 - ncbi.nlm.nih.gov
Background Neuroblastoma is the most common extracranial solid tumor of childhood.
Patients with high-risk disease undergo extremely aggressive therapy and nonetheless …
Patients with high-risk disease undergo extremely aggressive therapy and nonetheless …
Central memory phenotype drives success of checkpoint inhibition in combination with CAR T cells
K Toews, L Grunewald, S Schwiebert… - Molecular …, 2020 - Wiley Online Library
The immunosuppressive microenvironment in solid tumors is thought to form a barrier to the
entry and efficacy of cell‐based therapies such as chimeric antigen receptor (CAR) T cells …
entry and efficacy of cell‐based therapies such as chimeric antigen receptor (CAR) T cells …
Altered microtubule equilibrium and impaired thrombus stability in mice lacking RanBP10
I Meyer, S Kunert, S Schwiebert… - Blood, The Journal …, 2012 - ashpublications.org
The crucial function of blood platelets in hemostasis is to prevent blood loss by stable
thrombus formation. This process is driven by orchestrated mechanisms including several …
thrombus formation. This process is driven by orchestrated mechanisms including several …