More than 60 years ago, the effect whereby radiotherapy at one site may lead to regression
of metastatic cancer at distant sites that are not irradiated was described and called the …

Radiotherapy is generally used to treat a localised target that includes cancer. Increasingly,
evidence indicates that radiotherapy recruits biological effectors outside the treatment field …

The therapeutic application of ionizing radiation has been largely based on its cytocidal
power combined with the ability to selectively target tumors. Radiotherapy effects on survival …

Radiotherapy is under investigation for its ability to enhance responses to immunotherapy.
However, the mechanisms by which radiation induces anti-tumour T cells remain unclear …

Purpose: This study tested the hypothesis that the type of dose fractionation regimen
determines the ability of radiotherapy to synergize with anti–CTLA-4 antibody. Experimental …

PURPOSE: Ionizing radiation can reduce tumor growth outside the field of radiation, known
as the abscopal effect. Although it has been reported in multiple malignancies, the abscopal …

Purpose: Ionizing radiation therapy (RT) is an important component in the management of
breast cancer. Although the primary tumor can be successfully treated by surgery and RT …

Apoptotic cells have long been considered as intrinsically tolerogenic or unable to elicit
immune responses specific for dead cell-associated antigens. However, multiple stimuli can …

Background Preclinical studies have found radiotherapy enhances antitumour immune
responses. We aimed to assess disease control and pulmonary toxicity in patients who …

Remarkable progress has been made in defining a new understanding of the role of mRNA
translation and protein synthesis in human cancer. Translational control is a crucial …