Therapeutic targeting of the RB1 pathway in retinoblastoma with the oncolytic adenovirus VCN-01
G Pascual-Pasto, M Bazan-Peregrino… - Science translational …, 2019 - science.org
Retinoblastoma is a pediatric solid tumor of the retina activated upon homozygous
inactivation of the tumor suppressor RB1. VCN-01 is an oncolytic adenovirus designed to …
inactivation of the tumor suppressor RB1. VCN-01 is an oncolytic adenovirus designed to …
[HTML][HTML] Phase I, multicenter, open-label study of intravenous VCN-01 oncolytic adenovirus with or without nab-paclitaxel plus gemcitabine in patients with advanced …
R Garcia-Carbonero, M Bazan-Peregrino… - … for immunotherapy of …, 2022 - ncbi.nlm.nih.gov
Background VCN-01 is an oncolytic adenovirus (Ad5 based) designed to replicate in cancer
cells with dysfunctional RB1 pathway, express hyaluronidase to enhance virus intratumoral …
cells with dysfunctional RB1 pathway, express hyaluronidase to enhance virus intratumoral …
Oncolytic adenovirus with hyaluronidase activity that evades neutralizing antibodies: VCN-11
A Mato-Berciano, S Morgado, MV Maliandi… - Journal of Controlled …, 2021 - Elsevier
Tumor targeting and intratumoral virus spreading are key features for successful oncolytic
virotherapy. VCN-11 is a novel oncolytic adenovirus, genetically modified to express …
virotherapy. VCN-11 is a novel oncolytic adenovirus, genetically modified to express …