User profiles for "author:Simon C Robson"
Simon C. RobsonCharlotte F. and Irving W. Rabb Professor of Medicine at Harvard Medical School Verified email at bidmc.harvard.edu Cited by 44193 |
The ectonucleotidases CD 39 and CD 73: novel checkpoint inhibitor targets
Cancers are able to grow by subverting immune suppressive pathways, to prevent the
malignant cells as being recognized as dangerous or foreign. This mechanism prevents the …
malignant cells as being recognized as dangerous or foreign. This mechanism prevents the …
Purinergic signaling during inflammation
HK Eltzschig, MV Sitkovsky… - New England Journal of …, 2012 - Mass Medical Soc
Receptors for ATP and ADP and adenosine exert various effects. ATP and ADP signaling is
mainly proinflammatory, and adenosine signaling is mainly antiinflammatory. Receptors for …
mainly proinflammatory, and adenosine signaling is mainly antiinflammatory. Receptors for …
Ectonucleotidases as regulators of purinergic signaling in thrombosis, inflammation, and immunity
S Deaglio, SC Robson - Advances in pharmacology, 2011 - Elsevier
Evolving studies in models of transplant rejection, inflammatory bowel disease, and cancer,
among others, have implicated purinergic signaling in clinical manifestations of vascular …
among others, have implicated purinergic signaling in clinical manifestations of vascular …
Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression
S Deaglio, KM Dwyer, W Gao, D Friedman… - The Journal of …, 2007 - rupress.org
The study of T regulatory cells (T reg cells) has been limited by the lack of specific surface
markers and an inability to define mechanisms of suppression. We show that the expression …
markers and an inability to define mechanisms of suppression. We show that the expression …
Negative feedback control of neuronal activity by microglia
Microglia, the brain's resident macrophages, help to regulate brain function by removing
dying neurons, pruning non-functional synapses, and producing ligands that support …
dying neurons, pruning non-functional synapses, and producing ligands that support …
[HTML][HTML] The E-NTPDase family of ectonucleotidases: structure function relationships and pathophysiological significance
Ectonucleotidases are ectoenzymes that hydrolyze extracellular nucleotides to the
respective nucleosides. Within the past decade, ectonucleotidases belonging to several …
respective nucleosides. Within the past decade, ectonucleotidases belonging to several …
Heart transplantation in baboons using α1, 3-galactosyltransferase gene-knockout pigs as donors: initial experience
K Kuwaki, YL Tseng, FJMF Dor, A Shimizu… - Nature medicine, 2005 - nature.com
Abstract Hearts from α1, 3-galactosyltransferase knockout pigs (GalT-KO, n= 8) were
transplanted heterotopically into baboons using an anti-CD154 monoclonal antibody–based …
transplanted heterotopically into baboons using an anti-CD154 monoclonal antibody–based …
Coordinated Adenine Nucleotide Phosphohydrolysis and Nucleoside Signaling in Posthypoxic Endothelium: Role of Ectonucleotidases and Adenosine A2B …
Limited oxygen delivery to tissues (hypoxia) is common in a variety of disease states. A
number of parallels exist between hypoxia and acute inflammation, including the …
number of parallels exist between hypoxia and acute inflammation, including the …
[HTML][HTML] Identification and characterization of CD39/vascular ATP diphosphohydrolase
Vascular ATP diphosphohydrolase (ATPDase) is a plasma membrane-bound enzyme that
hydrolyses extracellular ATP and ADP to AMP. Analysis of amino acid sequences available …
hydrolyses extracellular ATP and ADP to AMP. Analysis of amino acid sequences available …
Targeted disruption of cd39/ATP diphosphohydrolase results in disordered hemostasis and thromboregulation
K Enjyoji, J Sévigny, Y Lin, PS Frenette, PD Christie… - Nature medicine, 1999 - nature.com
CD39, or vascular adenosine triphosphate diphosphohydrolase, has been considered an
important inhibitor of platelet activation. Unexpectedly, cd39-deficient mice had prolonged …
important inhibitor of platelet activation. Unexpectedly, cd39-deficient mice had prolonged …