User profiles for "author:Simon C Robson"

Simon C. Robson

Charlotte F. and Irving W. Rabb Professor of Medicine at Harvard Medical School
Verified email at bidmc.harvard.edu
Cited by 44193

The ectonucleotidases CD 39 and CD 73: novel checkpoint inhibitor targets

B Allard, MS Longhi, SC Robson… - Immunological …, 2017 - Wiley Online Library
Cancers are able to grow by subverting immune suppressive pathways, to prevent the
malignant cells as being recognized as dangerous or foreign. This mechanism prevents the …

Purinergic signaling during inflammation

HK Eltzschig, MV Sitkovsky… - New England Journal of …, 2012 - Mass Medical Soc
Receptors for ATP and ADP and adenosine exert various effects. ATP and ADP signaling is
mainly proinflammatory, and adenosine signaling is mainly antiinflammatory. Receptors for …

Ectonucleotidases as regulators of purinergic signaling in thrombosis, inflammation, and immunity

S Deaglio, SC Robson - Advances in pharmacology, 2011 - Elsevier
Evolving studies in models of transplant rejection, inflammatory bowel disease, and cancer,
among others, have implicated purinergic signaling in clinical manifestations of vascular …

Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression

S Deaglio, KM Dwyer, W Gao, D Friedman… - The Journal of …, 2007 - rupress.org
The study of T regulatory cells (T reg cells) has been limited by the lack of specific surface
markers and an inability to define mechanisms of suppression. We show that the expression …

Negative feedback control of neuronal activity by microglia

A Badimon, HJ Strasburger, P Ayata, X Chen, A Nair… - Nature, 2020 - nature.com
Microglia, the brain's resident macrophages, help to regulate brain function by removing
dying neurons, pruning non-functional synapses, and producing ligands that support …

[HTML][HTML] The E-NTPDase family of ectonucleotidases: structure function relationships and pathophysiological significance

SC Robson, J Sévigny, H Zimmermann - Purinergic signalling, 2006 - Springer
Ectonucleotidases are ectoenzymes that hydrolyze extracellular nucleotides to the
respective nucleosides. Within the past decade, ectonucleotidases belonging to several …

Heart transplantation in baboons using α1, 3-galactosyltransferase gene-knockout pigs as donors: initial experience

K Kuwaki, YL Tseng, FJMF Dor, A Shimizu… - Nature medicine, 2005 - nature.com
Abstract Hearts from α1, 3-galactosyltransferase knockout pigs (GalT-KO, n= 8) were
transplanted heterotopically into baboons using an anti-CD154 monoclonal antibody–based …

Coordinated Adenine Nucleotide Phosphohydrolysis and Nucleoside Signaling in Posthypoxic Endothelium: Role of Ectonucleotidases and Adenosine A2B …

HK Eltzschig, JC Ibla, GT Furuta, MO Leonard… - The Journal of …, 2003 - rupress.org
Limited oxygen delivery to tissues (hypoxia) is common in a variety of disease states. A
number of parallels exist between hypoxia and acute inflammation, including the …

[HTML][HTML] Identification and characterization of CD39/vascular ATP diphosphohydrolase

E Kaczmarek, K Koziak, J Sévigny, JB Siegel… - Journal of Biological …, 1996 - ASBMB
Vascular ATP diphosphohydrolase (ATPDase) is a plasma membrane-bound enzyme that
hydrolyses extracellular ATP and ADP to AMP. Analysis of amino acid sequences available …

Targeted disruption of cd39/ATP diphosphohydrolase results in disordered hemostasis and thromboregulation

K Enjyoji, J Sévigny, Y Lin, PS Frenette, PD Christie… - Nature medicine, 1999 - nature.com
CD39, or vascular adenosine triphosphate diphosphohydrolase, has been considered an
important inhibitor of platelet activation. Unexpectedly, cd39-deficient mice had prolonged …