[PDF][PDF] KMT2D deficiency drives lung squamous cell carcinoma and hypersensitivity to RTK-RAS inhibition
Lung squamous cell carcinoma (LUSC) represents a major subtype of lung cancer with
limited treatment options. KMT2D is one of the most frequently mutated genes in LUSC (> …
limited treatment options. KMT2D is one of the most frequently mutated genes in LUSC (> …
Targeting HER2 Exon 20 Insertion–Mutant Lung Adenocarcinoma with a Novel Tyrosine Kinase Inhibitor Mobocertinib
No targeted treatments are currently approved for HER2 exon 20 insertion–mutant lung
adenocarcinoma patients. Mobocertinib (TAK-788) is a potent irreversible tyrosine kinase …
adenocarcinoma patients. Mobocertinib (TAK-788) is a potent irreversible tyrosine kinase …
Loss of TSC1/TSC2 sensitizes immune checkpoint blockade in non–small cell lung cancer
Tuberous sclerosis complex subunit 1 (TSC1) and 2 (TSC2) are frequently mutated in non–
small cell lung cancer (NSCLC), however, their effects on antitumor immunity remained …
small cell lung cancer (NSCLC), however, their effects on antitumor immunity remained …
Targeting the Atf7ip–Setdb1 Complex Augments Antitumor Immunity by Boosting Tumor Immunogenicity
Substantial progress has been made in understanding how tumors escape immune
surveillance. However, few measures to counteract tumor immune evasion have been …
surveillance. However, few measures to counteract tumor immune evasion have been …
[HTML][HTML] Nemvaleukin alfa, a novel engineered IL-2 fusion protein, drives antitumor immunity and inhibits tumor growth in small cell lung cancer
Background Small cell lung cancer (SCLC) is a deadly disease with a 5-year survival of less
than 7%. The addition of immunotherapy to chemotherapy was recently approved as first …
than 7%. The addition of immunotherapy to chemotherapy was recently approved as first …
[HTML][HTML] Histone Deacetylase 6 Inhibition Exploits Selective Metabolic Vulnerabilities in LKB1 Mutant, KRAS Driven NSCLC
H Zhang, CS Nabel, D Li, RÍ O'Connor… - Journal of Thoracic …, 2023 - Elsevier
Abstract Introduction In KRAS-mutant NSCLC, co-occurring alterations in LKB1 confer a
negative prognosis compared with other mutations such as TP53. LKB1 is a tumor …
negative prognosis compared with other mutations such as TP53. LKB1 is a tumor …
Prolactin Induced Protein (PIP) is a potential biomarker for early stage and malignant breast cancer
A Gangadharan, T Nyirenda, K Patel… - The Breast, 2018 - Elsevier
Objectives Breast cancer (BC) is the second leading cause of cancer-related mortality in
women. Bioinformatic analysis and expression screening showed that Prolactin Induced …
women. Bioinformatic analysis and expression screening showed that Prolactin Induced …
Benefits of Telehealth across different socio-economic communities
G Lakenauth, S Tang - IEEE Long Island Systems, Applications …, 2014 - ieeexplore.ieee.org
Vital Care Services (VICS) is a Telehealth servicing company which addresses the national
healthcare issue by providing cost effective health and wellness solutions to patients …
healthcare issue by providing cost effective health and wellness solutions to patients …