[HTML][HTML] Myxoma virus sensitizes cancer cells to gemcitabine and is an effective oncolytic virotherapeutic in models of disseminated pancreatic cancer

ST Wennier, J Liu, S Li, MM Rahman, M Mona… - Molecular Therapy, 2012 - cell.com
Myxoma virus (MYXV) is a novel oncolytic virus that has been shown to replicate in
pancreatic cancer cells, but its efficacy in animal models of pancreatic cancer has not been …

M062 is a host range factor essential for myxoma virus pathogenesis and functions as an antagonist of host SAMD9 in human cells

J Liu, S Wennier, L Zhang, G McFadden - Journal of virology, 2011 - Am Soc Microbiol
ABSTRACT Myxoma virus (MYXV) M062R is a functional homolog of the C7L family of host
range genes from orthopoxviruses. We constructed a targeted M062R-knockout-MYXV …

[HTML][HTML] Synergistic cancer immunotherapy combines MVA-CD40L induced innate and adaptive immunity with tumor targeting antibodies

J Medina-Echeverz, M Hinterberger, M Testori… - Nature …, 2019 - nature.com
Virus-based vaccines and appropriate costimulation potently enhance antigen-specific T cell
immunity against cancer. Here we report the use of recombinant modified vaccinia virus …

[HTML][HTML] The immunoregulatory properties of oncolytic myxoma virus and their implications in therapeutics

J Liu, S Wennier, G McFadden - Microbes and infection, 2010 - Elsevier
Myxoma virus (MYXV) is a poxvirus with a strict rabbit-specific host-tropism for pathogenesis.
The immunoregulatory factors encoded by MYXV can suppress some functions of immune …

Oncolytic virotherapy for pancreatic cancer

S Wennier, S Li, G McFadden - Expert reviews in molecular medicine, 2011 - cambridge.org
Within the past decade, many oncolytic viruses (OVs) have been studied as potential
treatments for pancreatic cancer and some of these are currently under clinical trials. The …

Aromatic amino acids in the juxtamembrane domain of severe acute respiratory syndrome coronavirus spike glycoprotein are important for receptor-dependent virus …

MW Howard, EA Travanty, SA Jeffers, MK Smith… - Journal of …, 2008 - Am Soc Microbiol
The severe acute respiratory syndrome coronavirus (SARS-CoV) spike glycoprotein (S) is a
class I viral fusion protein that binds to its receptor glycoprotein, human angiotensin …

[HTML][HTML] Intratumoral virotherapy with 4-1BBL armed modified vaccinia Ankara eradicates solid tumors and promotes protective immune memory

M Hinterberger, R Giessel, G Fiore… - … for Immunotherapy of …, 2021 - ncbi.nlm.nih.gov
Background Human cancers are extraordinarily heterogeneous in terms of tumor antigen
expression, immune infiltration and composition. A common feature, however, is the host′ s …

[HTML][HTML] A novel naturally occurring tandem promoter in modified vaccinia virus ankara drives very early gene expression and potent immune responses

ST Wennier, K Brinkmann, C Steinhäußer… - PLoS …, 2013 - journals.plos.org
Modified vaccinia virus Ankara (MVA) has been shown to be suitable for the generation of
experimental vaccines against cancer and infectious diseases, eliciting strong humoral and …

Myxoma virus expressing interleukin-15 fails to cause lethal myxomatosis in European rabbits

J Liu, S Wennier, M Reinhard, E Roy… - Journal of …, 2009 - Am Soc Microbiol
Myxoma virus (MYXV) is a poxvirus pathogenic only for European rabbits, but its
permissiveness in human cancer cells gives it potential as an oncolytic virus. A recombinant …

Myxoma virus M064 is a novel member of the poxvirus C7L superfamily of host range factors that controls the kinetics of myxomatosis in European rabbits

J Liu, S Wennier, N Moussatche, M Reinhard… - Journal of …, 2012 - Am Soc Microbiol
The myxoma virus (MYXV) carries three tandem C7L-like host range genes (M062R,
M063R, and M064R). However, despite the fact that the sequences of these three genes are …