NK cells are capable of an array of functions that range widely from their classic anti-tumor
and anti-viral cytotoxic effector functions, to their critical regulatory roles in controlling …

As highlighted by the COVID-19 global pandemic, elderly individuals comprise the majority
of cases of severe viral infection outcomes and death. A combined inability to control viral …

Metabolic flux can dictate cell fate, including immune cell effector and regulatory function.
The metabolic regulation of cell function is well characterized with respect to effector …

NK cells are central to anti-tumor immunity and recently showed efficacy for treating
hematologic malignancies. However, their dysfunction in the hostile tumor microenvironment …

The synergistic effect of IL-18/IL-15/IL-12 stimulation potently activates NK cells, inducing
high levels of IFN-γ production. As a result of this potent stimulatory effect, NK cell pre …

Despite the remarkable success of chimeric antigen receptor (CAR)-T cells against
hematologic malignancies, severe off-tumor effects have constrained their use against solid …

Natural killer (NK) cells are useful for cancer immunotherapy and have proven clinically
effective against hematologic malignancies. However, immunotherapies for poor prognosis …

Lung cancer remains the leading cause of cancer death worldwide despite the significant
progress made by immune checkpoint inhibitors, including programmed death receptor-1 …

Ovarian cancer (OC) is the leading cause of gynecological cancer-related death in North
America. Most ovarian cancer patients (OCPs) experience disease recurrence after first-line …

With over 600,000 units of umbilical cord blood (CB) stored on a global scale, it is important
to elucidate the therapeutic abilities of this cryopreserved reservoir. In the advancing field of …